Over the past two decades, research has heavily emphasized basic mechanisms that
irreversibly damage brain cells after stroke. Much attention has focused on what makes …

Induced hypothermia is proposed as a treatment for acute ischaemic stroke, but there have
been too few clinical trials involving too few patients to draw any conclusions about the …

Background A hypoxic-ischaemic insult occurring around the time of birth may result in an
encephalopathic state characterised by the need for resuscitation at birth, neurological …

Voluntary exercise, treadmill activity, skills training, and forced limb use have been utilized in
animal studies to promote brain plasticity and functional change. Motor enrichment may …

The past decade of neuroscience research has provided considerable evidence that the
adult brain can undergo substantial reorganization following injury. For example, following …

The possibility that hypothermia during or after resuscitation from asphyxia at birth, or
cardiac arrest in adults, might reduce evolving damage has tantalized clinicians for a very …

Object Hypothermia is by far the most potent neuroprotectant. Nevertheless, timely and safe
delivery of hypothermia remains a clinical challenge. To maximize neuroprotection yet …

Acute ischemic stroke is treatable, and our ability to treat patients with ischemic stroke
continues to improve. Since the publication of the first edition of this book, important changes …

Delayed but prolonged hypothermia persistently decreases cell death and functional deficits
after global cerebral ischemia in rodents. Postischemic hypothermia also reduces infarction …

In cerebral ischemia survival of neurons, astrocytes, oligodendrocytes and endothelial cells
is threatened during energy deprivation and/or following re-supply of oxygen and glucose …