Cysteine plays an essential role in cellular redox homoeostasis as a key constituent of the
tripeptide glutathione (GSH). A rate limiting step in cellular GSH synthesis is the availability …

Found in all domains of life, transporters belonging to the LeuT-fold class mediate the import
and exchange of hydrophilic and charged compounds such as amino acids, metals, and …

Amino acids derived from protein digestion are important nutrients for the growth and
maintenance of organisms. Approximately half of the 20 proteinogenic amino acids can be …

Amino acid homeostasis is maintained by import, export, oxidation, and synthesis of
nonessential amino acids, and by the synthesis and breakdown of protein. These processes …

Abstract LAT1 (SLC7A5) is one of the representative light chain proteins of heteromeric
amino acid transporters, forming a heterodimer with its heavy chain partner 4F2hc …

The Amino Acid–Polyamine-Organocation (APC) transporter GadC contributes to the
survival of pathogenic bacteria under extreme acid stress by exchanging extracellular …

Despite having similar structures, each member of the heteromeric amino acid transporter
(HAT) family shows exquisite preference for the exchange of certain amino acids. Substrate …

Solute carriers form one of three major superfamilies of membrane transporters in humans,
and include uniporters, exchangers and symporters. Following several decades of …

Cystinuria is a genetic disorder caused by defects in the b0,+ transporter system, which is
composed of rBAT and b0,+ AT coded by SLC3A1 and SLC7A9, respectively. Variants in …

Abstract The Alanine-Serine-Cysteine transporter 1 (Asc-1 or SLC7A10) forms a crucial
heterodimeric transporter complex with 4F2hc (SLC3A2) through a covalent disulfide bridge …