Mitochondria not only synthesize energy required for cellular functions but are also involved
in numerous cellular pathways including apoptosis, calcium homoeostasis, inflammation …

Dynamins are large GTPases that belong to a protein superfamily that, in eukaryotic cells,
includes classical dynamins, dynamin-like proteins, OPA1, Mx proteins, mitofusins and …

Mitochondria are derived from eubacteria; however, in most eukaryotes, novel mechanisms
for the propagation of this organelle and its genome have evolved. This review focuses on …

Mitochondria are dynamic organelles that undergo cycles of fission and fusion. The yeast
dynamin-related protein Dnm1 has been localized to sites of mitochondrial division. Using …

GTP-binding (G) proteins constitute a class of P-loop (phosphate-binding loop) proteins that
work as molecular switches between the GDP-bound OFF and the GTP-bound ON state. The …

Dynamin 1‐like protein (DNM1L) mediates fission of mitochondria and peroxisomes, and
dysfunction of DNM1L has been implicated in several neurological disorders. To study the …

Dynamin is a mechanochemical GTPase that oligomerizes around the neck of clathrin-
coated pits and catalyses vesicle scission in a GTP-hydrolysis-dependent manner. The …

Mx proteins are interferon‐induced GTPases that belong to the dynamin superfamily of large
GTPases. Similarities include a high molecular weight, a propensity to self‐assemble, a …

Dynamin is an atypical GTPase that catalyses membrane fission during clathrin-mediated
endocytosis. The mechanisms of dynamin's basal and assembly-stimulated GTP hydrolysis …

Dynamin-related proteins (DRPs) are multi-domain GTPases that function via
oligomerization and GTP-dependent conformational changes to play central roles in …