Cell-derived matrices for tissue engineering and regenerative medicine applications

LE Fitzpatrick, TC McDevitt - Biomaterials science, 2015 - pubs.rsc.org
The development and application of decellularized extracellular matrices (ECM) has grown
rapidly in the fields of cell biology, tissue engineering and regenerative medicine in recent …

Mesenchymal stem cells as a cornerstone in a galaxy of intercellular signals: basis for a new era of medicine

S Fernández-Francos, N Eiro, LA Costa… - International journal of …, 2021 - mdpi.com
Around 40% of the population will suffer at some point in their life a disease involving tissue
loss or an inflammatory or autoimmune process that cannot be satisfactorily controlled with …

Mesenchymal (Stem) stromal cells based as new therapeutic alternative in inflammatory bowel disease: basic mechanisms, experimental and clinical evidence, and …

N Eiro, M Fraile, A González-Jubete… - International journal of …, 2022 - mdpi.com
Inflammatory bowel diseases (IBD) are an example of chronic diseases affecting 40% of the
population, which involved tissue damage and an inflammatory process not satisfactorily …

Mesenchymal stem cell-based therapy as an alternative to the treatment of acute respiratory distress syndrome: current evidence and future perspectives

S Fernández-Francos, N Eiro… - International journal of …, 2021 - mdpi.com
Acute respiratory distress syndrome (ARDS) represents a current challenge for medicine
due to its incidence, morbidity and mortality and, also, the absence of an optimal treatment …

Bone defect reconstruction via endochondral ossification: A developmental engineering strategy

R Fu, C Liu, Y Yan, Q Li… - Journal of tissue …, 2021 - journals.sagepub.com
Traditional bone tissue engineering (BTE) strategies induce direct bone-like matrix formation
by mimicking the embryological process of intramembranous ossification. However, the …

Manufacturing of human tissues as off‐the‐shelf grafts programmed to induce regeneration

S Pigeot, T Klein, F Gullotta, SJ Dupard… - Advanced …, 2021 - Wiley Online Library
Abstract Design criteria for tissue‐engineered materials in regenerative medicine include
robust biological effectiveness, off‐the‐shelf availability, and scalable manufacturing under …

Improving the safety of cell therapy with the TK-suicide gene

R Greco, G Oliveira, MTL Stanghellini, L Vago… - Frontiers in …, 2015 - frontiersin.org
While opening new frontiers for the cure of malignant and non-malignant diseases, the
increasing use of cell therapy poses also several new challenges related to the safety of a …

Engineering of immunoinstructive extracellular matrices for enhanced osteoinductivity

A García-García, S Pigeot, I Martin - Bioactive Materials, 2023 - Elsevier
The increasing recognition of the contribution of the immune system to activate and prime
regeneration implies that tissue engineering strategies and biomaterials design should …

Engineering human mini-bones for the standardized modeling of healthy hematopoiesis, leukemia, and solid tumor metastasis

A Grigoryan, D Zacharaki, A Balhuizen… - Science translational …, 2022 - science.org
The bone marrow microenvironment provides indispensable factors to sustain blood
production throughout life. It is also a hotspot for the progression of hematologic disorders …

Vector engineering, strategies and targets in cancer gene therapy

V Singh, N Khan, GR Jayandharan - Cancer Gene Therapy, 2022 - nature.com
Understanding the molecular basis of disease and the design of rationally designed
molecular therapies has been the holy grail in the management of human cancers. Gene …