Solid lipid nanoparticles (SLNs), the spheroidal-shaped, colloids state lipophilic-natured,
innovative nanoscale particulate materials, are being concurrently prepared by the quality …

Contemporary trends in combinatorial chemistry and the design of pharmaceuticals
targeting brain disorders have favored the development of drug candidates with increased …

Abstract Background and Purpose Following traumatic brain injury, inflammation,
mitochondrial dysfunction, oxidative stress, ischemia, and energy crisis can cause mortality …

Definition Solid lipid nanoparticles (SLNs) are produced from physiologically biocompatible
lipids. They have been proven to improve solubility, cellular uptake, and stability, reduce …

Novel drug delivery system opens the doors towards nano/micro formulation strategies to
overcome the challenges associated with the poorly soluble and permeable drugs. Lipid …

The clinical use of nonsteroidal anti-inflammatory drugs is limited by their poor water
solubility, unstable absorption, and low bioavailability. Solid lipid nanoparticles (SLNs) …

Efficient oral delivery of drugs treating brain diseases has long been a challenging topic
faced by the drug delivery community. Fortunately, polyester nanoparticles offer certain …

Bromocriptine (BCR) presents poor bioavailability when administered orally because of its
low solubility and prolonged first-pass metabolism. This poses a significant challenge in its …

Parkinson's disease (PD) is a prevalent neurodegenerative disorder, primarily associated
with dopaminergic neuron depletion in the Substantia Nigra. Current treatment focuses on …

Background Glioblastoma (GBM), a primary malignant brain tumor, has a poor prognosis,
even with standard treatments such as radiotherapy and chemotherapy. In this study, we …