Background Recent study of the inflammatory reactions occurring during and after
cardiopulmonary bypass (CPB) has improved our understanding of the involvement of the …

The term ischemia-reperfusion injury describes the experimentally and clinically prevalent
finding that tissue ischemia with inadequate oxygen supply followed by successful …

Objectives. The purpose of this study was to examine whether tumor necrosis factor-alpha
(TNF-alpha) is released directly from the ischemic myocardium undergoing reperfusion …

Ischemic myocardium must be reperfused to terminate the ischemic event; otherwise the
entire myocardium involved in the area at risk will not survive. However, there is a cost to …

Objective: To discover the possible effects of methylprednisolone on the systemic
inflammatory response during aprotinin treatment. Design: Randomized, double-blinded …

The efficacy of the serine protease inhibitor, aprotinin, and the lysine analogs, ε-
aminocaproic acid and tranexamic acid, in reducing bleeding and transfusion in adults …

The decision to use any pharmacologic intervention inevitably rests on balancing the
efficacy and safety of the intervention. The advent of the acquired immunodeficiency …

Myocardial ischemia-reperfusion (I/R) is associated with the activation of matrix
metalloproteinases (MMPs) and serine proteases. We hypothesized that activation of MMPs …

Cardiopulmonary bypass has been shown to activate various inflammatory cascades in the
body, resulting in pathophysiological changes that may affect patient outcome after cardiac …

Background Impairment of left ventricular function after cardiopulmonary bypass (CPB) is
well recognized, but little is known about the time course of recovery of cardiac function early …