The scientific landscape surrounding amyotrophic lateral sclerosis (ALS) continues to shift
as the number of genes associated with the disease risk and pathogenesis, and the cellular …

Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD) are two
neurological diseases which, respectively, and primarily affect motor neurons and …

Mitochondrial dysfunction occurs in numerous neurodegenerative diseases, particularly
amyotrophic lateral sclerosis (ALS), where it contributes to motor neuron (MN) death. Of all …

Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron disease affecting both
upper and lower motor neurons and leading to progressive paralysis. Most cases are …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects
nerve cells in the brain and spinal cord. More than 25 ALS-related genes have been …

Objective Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease
associated with upper and lower motor neuron degeneration and necrosis, characterized by …

Neuromuscular diseases are a diverse group of conditions that affect the motor system and
present some overlapping as well as distinct clinical manifestations. Although individually …

Motor neuron disorders are a group of neurodegenerative diseases characterized by muscle
weakness, loss of ambulation, respiratory insufficiency, leading to an early death. Spinal …

Autosomal dominant mutations in the gene encoding the DNA and RNA binding protein FUS
are a cause of amyotrophic lateral sclerosis (ALS), and about 0· 3–0· 9% of patients with …

3. Results A total of 1633 ALS patients were included. Thirty out of 1633 patients (1.8%) met
our criteria for SA ALS. Although excluded from the analysis, we identified two additional …