Alzheimer disease (AD) is the most common cause of dementia in older individuals. AD is
characterized pathologically by amyloid-β (Aβ) plaques and tau neurofibrillary tangles in the …

Soil naturally comprises heavy metals but due to the rapid industrialization and
anthropogenic events such as uncontrolled use of agrochemicals their concentration is …

Intracellular delivery is a key step in biological research and has enabled decades of
biomedical discoveries. It is also becoming increasingly important in industrial and medical …

Simultaneous targeting of both the tumor microenvironment and cancer cells by a single
nanomedicine has not been reported to date. Here, we report the dual properties of zero …

Dendritic cells have the ability to efficiently present internalized antigens on major
histocompatibility complex (MHC) I molecules. This process is termed cross-presentation …

Oxidized phospholipids that result from tissue injury operate as immunomodulatory signals
that, depending on the context, lead to proinflammatory or anti-inflammatory responses. In …

Abstract Type 1 conventional dendritic (cDC1) cells are necessary for cross-presentation of
many viral and tumor antigens to CD8+ T cells. cDC1 cells can be identified in mice and …

With modern day urbanization and industrialization, heavy metal (HM) contamination has
become a prime concern for today's society. The impacts of metal contamination on …

Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOX) are enzymes that
generate superoxide or hydrogen peroxide from molecular oxygen utilizing NADPH as an …

Adjuvants are indispensable components of vaccines for stimulating optimal immune
responses to non-replicating, inactivated and subunit antigens. Eliciting balanced humoral …