In the last decade, the sequence-specific transcription factor double homeobox 4 (DUX4)
has gone from being an obscure entity to being a key factor in important physiological and …

As the only striated muscle tissues in the body, skeletal and cardiac muscle share numerous
structural and functional characteristics, while exhibiting vastly different size and …

Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal dominant or digenic
disorder linked to derepression of the toxic DUX4 gene in muscle. There is currently no …

Facioscapulohumeral muscular dystrophy (FSHD) is characterized by misexpression of the
double homeobox 4 (DUX4) developmental transcription factor in mature skeletal muscle …

Facioscapulohumeral muscular dystrophy (FSHD) is caused by incomplete silencing of the
disease locus, leading to pathogenic misexpression of DUX4 in skeletal muscle. Previously …

Muscular dystrophies (MDs) encompass a wide variety of inherited disorders that are
characterized by loss of muscle tissue associated with a progressive reduction in muscle …

Facioscapulohumeral muscular dystrophy (FSHD) is a common muscle dystrophy typically
affecting patients within their second decade. Patients initially exhibit asymmetric facial and …

Dysferlin is an integral membrane protein of the transverse tubules of skeletal muscle that is
mutated or absent in limb girdle muscular dystrophy 2B and Miyoshi myopathy. Here we …

Human DUX4 and its mouse ortholog Dux are normally expressed in the early embryo—the
4-cell or 2-cell cleavage stage embryo, respectively—and activate a portion of the first wave …

Xenografts of human skeletal muscle generated in mice can be used to study muscle
pathology and to test drugs designed to treat myopathies and muscular dystrophies for their …