Angiogenesis is a highly coordinated process of formation of new blood vessels from pre-
existing blood vessels. The process of development of the proper vascular network is a …

The burden of cardiovascular and metabolic diseases worldwide is staggering. The
emergence of systems approaches in biology promises new therapies, faster and cheaper …

Vascular endothelial cells (ECs) are exposed to hemodynamic forces, which modulate EC
functions and vascular biology/pathobiology in health and disease. The flow patterns and …

In development, tissue regeneration or certain diseases, angiogenic growth leads to the
expansion of blood vessels and the lymphatic vasculature. This involves endothelial cell …

The vascular system is locally specialized to accommodate widely varying blood flow and
pressure and the distinct needs of individual tissues. The endothelial cells (ECs) that line the …

The study of angiogenesis has grown exponentially over the past 40 years with the
recognition that angiogenesis is essential for numerous pathologies and, more recently, with …

Costimulatory signals are required for activation of immune cells, but it is not known whether
they contribute to other biological systems. The development and homeostasis of the …

Formation of a fully functional artery proceeds through a multistep process. Here we show
that Notch3 is required to generate functional arteries in mice by regulating arterial …

Microplastics are a contaminant of emergent concern in the environment, however, to date
there is a limited understanding on their movement within organisms and the response of …

Vascular plants have a long-distance transport system consisting of two tissue types with
elongated cell files, phloem and xylem. Phloem has two basic cell types, enucleate sieve …