Tumour mutational burden: clinical utility, challenges and emerging improvements
Tumour mutational burden (TMB), defined as the total number of somatic non-synonymous
mutations present within the cancer genome, varies across and within cancer types. A first …
mutations present within the cancer genome, varies across and within cancer types. A first …
Systematic discovery of neoepitope–HLA pairs for neoantigens shared among patients and tumor types
HR Gurung, AJ Heidersbach, M Darwish… - Nature …, 2024 - nature.com
The broad application of precision cancer immunotherapies is limited by the number of
validated neoepitopes that are common among patients or tumor types. To expand the …
validated neoepitopes that are common among patients or tumor types. To expand the …
Engineering T-cell receptor–like antibodies for biologics and cell therapy
LS Høydahl, G Berntzen, GÅ Løset - Current Opinion in Biotechnology, 2024 - Elsevier
Highlights•Immunotherapy targeting pHLA has entered the clinical stage.•pHLA targets
significantly expands ability to treat diseases with unmet need.•TCR-like antibodies are a …
significantly expands ability to treat diseases with unmet need.•TCR-like antibodies are a …
Emerging potential of immunopeptidomics by mass spectrometry in cancer immunotherapy
Y Minegishi, Y Haga, K Ueda - Cancer Science, 2024 - Wiley Online Library
With significant advances in analytical technologies, research in the field of cancer
immunotherapy, such as adoptive T cell therapy, cancer vaccine, and immune checkpoint …
immunotherapy, such as adoptive T cell therapy, cancer vaccine, and immune checkpoint …
Recurrent hepatocellular carcinoma is associated with the enrichment of MYC targets gene sets, elevated high confidence deleterious mutations and alternative …
O Karaosmanoğlu - Advances in Medical Sciences, 2025 - Elsevier
Purpose Recurrence is the main cause of hepatocellular carcinoma (HCC) related deaths.
Underlying recurrence biology can be better understood by comparative analysis of the …
Underlying recurrence biology can be better understood by comparative analysis of the …
INAEME: Integral Neoantigen Analysis with Entirety of Mutational Events
V Kovacevic, OS Milicevic, NM Ilic Raicevic, M Kojicic… - bioRxiv, 2023 - biorxiv.org
Neoantigens are peptides on the surface of cancer cells presented to the immune system.
Multiple novel therapeutic approaches involve the administration of neoantigens to trigger …
Multiple novel therapeutic approaches involve the administration of neoantigens to trigger …
[引用][C] Introduction to the Special Issue: The Immunopeptidome.
É Caron, C Perreault - Seminars in Immunology, 2023 - europepmc.org
Introduction to the Special Issue: The Immunopeptidome. - Abstract - Europe PMC Sign in |
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