RNA splicing and cancer

E Wang, I Aifantis - Trends in cancer, 2020 - cell.com
RNA splicing is an essential process that governs many aspects of cellular proliferation,
survival, and differentiation. Considering the importance of RNA splicing in gene regulation …

Alternative splicing and related RNA binding proteins in human health and disease

Y Tao, Q Zhang, H Wang, X Yang, H Mu - Signal Transduction and …, 2024 - nature.com
Alternative splicing (AS) serves as a pivotal mechanism in transcriptional regulation,
engendering transcript diversity, and modifications in protein structure and functionality …

YBX1 is required for maintaining myeloid leukemia cell survival by regulating BCL2 stability in an m6A-dependent manner

M Feng, X Xie, G Han, T Zhang, Y Li… - Blood, The Journal …, 2021 - ashpublications.org
RNA-binding proteins (RBPs) are critical regulators of transcription and translation that are
often dysregulated in cancer. Although RBPs are increasingly recognized as being …

Defining the RBPome of primary T helper cells to elucidate higher-order Roquin-mediated mRNA regulation

KP Hoefig, A Reim, C Gallus, EH Wong… - Nature …, 2021 - nature.com
Post-transcriptional gene regulation in T cells is dynamic and complex as targeted
transcripts respond to various factors. This is evident for the Icos mRNA encoding an …

Spliceosomal GTPase Eftud2 deficiency-triggered ferroptosis leads to Purkinje cell degeneration

G Yang, Y Yang, Z Song, L Chen, F Liu, Y Li, S Jiang… - Neuron, 2024 - cell.com
Summary Spliceosomal GTPase elongation factor Tu GTP binding domain containing 2
(EFTUD2) is a causative gene for mandibulofacial dysostosis with microcephaly (MFDM) …

Translation efficiency driven by CNOT3 subunit of the CCR4-NOT complex promotes leukemogenesis

M Ghashghaei, Y Liu, J Ettles, G Bombaci… - Nature …, 2024 - nature.com
Protein synthesis is frequently deregulated during tumorigenesis. However, the precise
contexts of selective translational control and the regulators of such mechanisms in cancer is …

RNA-binding proteins as regulators of migration, invasion and metastasis in oral squamous cell carcinoma

J Weiße, J Rosemann, V Krauspe, M Kappler… - International Journal of …, 2020 - mdpi.com
Nearly 7.5% of all human protein-coding genes have been assigned to the class of RNA-
binding proteins (RBPs), and over the past decade, RBPs have been increasingly …

Based on the cancer genome atlas database development of a prognostic model of RNA binding protein in stomach adenocarcinoma

SHA Raza, R Zhong, S Xing, X Yu… - Computers in Biology …, 2023 - Elsevier
The purpose of this study was to identify potential RNA binding proteins associated with the
survival of gastric adenocarcinoma, as well as the corresponding biological characteristics …

ThPOK is a critical multifaceted regulator of myeloid lineage development

J Basu, A Olsson, K Ferchen, EK Titerina, K Chetal… - Nature …, 2023 - nature.com
The transcription factor ThPOK (encoded by Zbtb7b) is well known for its role as a master
regulator of CD4 lineage commitment in the thymus. Here, we report an unexpected and …

The role of RNA-binding proteins in hematological malignancies

P Aguilar-Garrido, A Otero-Sobrino… - International Journal of …, 2022 - mdpi.com
Hematological malignancies comprise a plethora of different neoplasms, such as leukemia,
lymphoma, and myeloma, plus a myriad of dysplasia, such as myelodysplastic syndromes or …