Non-small cell lung cancer targeted therapy: drugs and mechanisms of drug resistance

J Wu, Z Lin - International journal of molecular sciences, 2022 - mdpi.com
The advent of precision medicine has brought light to the treatment of non-small cell lung
cancer (NSCLC), expanding the options for patients with advanced NSCLC by targeting …

HER2-targeted therapies in cancer: a systematic review

K Zhu, X Yang, H Tai, X Zhong, T Luo, H Zheng - Biomarker Research, 2024 - Springer
Abnormal alterations in human epidermal growth factor receptor 2 (HER2, neu, and erbB2)
are associated with the development of many tumors. It is currently a crucial treatment for …

Delivery of Drugs into Cancer Cells Using Antibody–Drug Conjugates Based on Receptor-Mediated Endocytosis and the Enhanced Permeability and Retention Effect

T Tashima - Antibodies, 2022 - mdpi.com
Innumerable people worldwide die of cancer every year, although pharmaceutical therapy
has actualized many benefits in human health. For background, anti-cancer drug …

Antibody–drug conjugates: Ushering in a new era of cancer therapy

J Hurwitz, LR Haggstrom, E Lim - Pharmaceutics, 2023 - mdpi.com
Antibody–drug conjugates (ADCs) have provided new therapeutic options and significant
promise for patients with cancer, particularly where existing treatments are limited …

Research progress in targeted therapy and immunotherapy for gastric cancer

X Li, J Xu, J Xie, W Yang - Chinese Medical Journal, 2022 - journals.lww.com
Gastric cancer (GC) is one of the most common malignant tumors worldwide. Its incidence
ranks the 5th among all malignant tumors globally, and it is the 3rd leading cause of death …

“SMART” digital nucleic acid amplification technologies for lung cancer monitoring from early to advanced stages

Y Ren, L Cao, M You, J Ji, Y Gong, H Ren, F Xu… - TrAC Trends in …, 2022 - Elsevier
Recently, liquid biopsy based on detection of circulating nucleic acid (NA) biomarkers from
body fluids has emerged as a promising strategy for lung cancer monitoring. Considering …

Molecular pathways, resistance mechanisms and targeted interventions in non-small-cell lung cancer

Z Wang, Y Xing, B Li, X Li, B Liu, Y Wang - Molecular biomedicine, 2022 - Springer
Lung cancer is the leading cause of cancer-related mortality worldwide. The discovery of
tyrosine kinase inhibitors effectively targeting EGFR mutations in lung cancer patients in …

Preparation of trastuzumab-DM1 conjugate with a high drug-to-antibody ratio for breast cancer therapy

H Zhang, Z Zhang, X Wang, D Wang, H Xu, Z Liu… - Nano Today, 2024 - Elsevier
Antibody-drug conjugates (ADCs) are important in active tumor-targeting therapy. However,
improving the efficiency of payload delivery to tumors without affecting the tumor-targeting …

Liquid biopsy based HER2 amplification status in gastric cancer patients indicates clinical response

S Klein-Scory, S Ladigan-Badura, T Mika, B Verdoodt… - Heliyon, 2023 - cell.com
Gastric carcinomas are among the most common cancers in Germany, with approximately
18,000 new cases per year. About 10 years ago, based on results of the Trastuzumab for …

UGT1A1 Testing in Breast Cancer: should it become routine practice in patients treated with antibody-drug conjugates?

R Ibrahim, R Khoury, T Ibrahim, A Le Cesne… - Critical Reviews in …, 2024 - Elsevier
The use of genetic testing to personalize therapeutic strategies in cancer is rapidly evolving
and thus changing the landscape of treatment of oncologic patients. The UGT1A1 gene is an …