Natural killer (NK) cells can swiftly kill multiple adjacent cells if these show surface markers
associated with oncogenic transformation. This property, which is unique among immune …

Major advances in preventing, delaying, or curing individual pathologies are responsible for
an increasingly long life span in the developed parts of our planet, and indeed reaching …

During human CMV infection, there is a preferential expansion of natural killer (NK) cells
expressing the activating CD94–NKG2C receptor complex, implicating this receptor in the …

Human aging is characterized by both physical and physiological frailty. A key feature of
frailty, sarcopenia is the age-associated decline in skeletal muscle mass, strength, and …

Forming the first line of defence against virally infected and malignant cells, natural killer
(NK) cells are critical effector cells of the innate immune system. With age, significant …

Human NK cells are innate immune effectors that play a critical roles in the control of viral
infection and malignancy. The importance of their homeostasis and function can be …

Natural killer (NK) cells are circulating cytotoxic lymphocytes that exert potent and
nonredundant antiviral activity and antitumoral activity in the mouse; however, their function …

Purpose: Anticancer T-cell responses can control tumors, but immunosuppressive
mechanisms in vivo prevent their function. The role of regulatory T cells (Tregs) in metastatic …

Interest in harnessing natural killer (NK) cells for cancer immunotherapy is rapidly growing.
However, efficacy of NK cell-based immunotherapy remains limited in most trials. Strategies …

Aging is characterized by the progressive decline of physiological function and tissue
homeostasis leading to increased vulnerability, degeneration, and death. Aging‐related …