Research in the field of hepatology is limited by the incomplete recapitulation of all major
aspects of human hepatic metabolism in most established models. This restricts our ability to …

Dissemination of malignant cells from primary tumours to metastatic sites is a key step in
cancer progression. Disseminated tumour cells preferentially settle in specific target organs …

Liver disease represents an increasing cause of global morbidity and mortality. Currently,
liver transplant is the only treatment curative for end-stage liver disease. Donor organs …

A major bottleneck in the study of human liver physiology is the provision of stable liver
tissue in sufficient quantity. As a result, current approaches to modelling human drug efficacy …

Lentiviral vectors (LV) are attractive for permanent and effective gene therapy. However,
integration into the host genome can cause insertional mutagenesis highlighting the …

Three-dimensional (3D) cell culture systems have become very popular in the field of drug
screening and discovery. There is an immense demand for highly efficient and easy …

The debate about possible adverse effects of bisphenol A (BPA) has been ongoing for
decades. Bisphenol F (BPF) and S (BPS) have been suggested as “safer” alternatives. In the …

Background: Liver disease secondary to an inborn or genetic error of metabolism is a rare
group of conditions often associated with chronic ill health and reduced survival. Curative …

Renewable and scalable human liver tissue platforms are a powerful tool to study organ
physiology and model diseases, such as cancer. Stem cell-derived models provide an …

Liver disease is a global health issue. Although the liver is capable of regeneration, in the
presence of severe organ injury this process is impaired. Although liver transplantation can …