Primary cutaneous T cell lymphomas (CTCLs) are a heterogeneous group of lymphomas
that present in the skin with no evidence of extracutaneous disease at the time of diagnosis …

Many cellular functions are regulated by calcium (Ca2+) signals that are generated by
different signaling pathways. One of these is the inositol 1, 4, 5-trisphosphate/calcium …

Cutaneous T cell lymphomas (CTCL) are rare but aggressive cancers without effective
treatments. While a subset of patients derive benefit from PD-1 blockade, there is a critically …

Cutaneous T cell lymphoma (CTCL) is a non-Hodgkin lymphoma of skin-homing T
lymphocytes. We performed exome and whole-genome DNA sequencing and RNA …

Sézary syndrome is a leukemic and aggressive form of cutaneous T cell lymphoma (CTCL)
resulting from the malignant transformation of skin-homing central memory CD4+ T cells …

T cell non-Hodgkin lymphomas are a heterogeneous group of highly aggressive
malignancies with poor clinical outcomes. T cell lymphomas originate from peripheral T cells …

Angioimmunoblastic T-cell lymphoma (AITL) and other lymphomas derived from follicular T-
helper cells (TFH) represent a large proportion of peripheral T-cell lymphomas (PTCLs) with …

Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum
of pleiotropic effects in cell growth and differentiation that are relevant for embryonic …

Sézary syndrome is a rare leukemic form of cutaneous T cell lymphoma characterized by
generalized redness, scaling, itching and increased numbers of circulating atypical T …

Mycosis fungoides and Sézary syndrome comprise the majority of cutaneous T cell
lymphomas (CTCLs), disorders notable for their clinical heterogeneity that can present in …