Asthma varies considerably across the life course. Childhood asthma is known for its overall
high prevalence with a male predominance prior to puberty, common remission, and rare …

Chronic respiratory diseases, such as chronic obstructive pulmonary disease (COPD),
asthma and interstitial lung diseases are frequently occurring disorders with a polygenic …

Background Children with moderate-to-severe asthma continue to have disease
complications despite the receipt of standard-of-care therapy. The monoclonal antibody …

Asthma is a heterogeneous disease that results from the complex interaction between
genetic factors and environmental exposures that occur at critical periods throughout life. It …

COPD, characterized by long-term poorly irreversible airway limitation and persistent
respiratory symptoms, has resulted in enormous challenges to human health worldwide …

Early life represents a critical period for the development and growth of the lungs. Adverse
exposures in this stage may drive the development of chronic obstructive pulmonary disease …

Asthma is a common disorder of the airways characterized by airway inflammation and by
decline in lung function and airway remodeling in a subset of asthmatics. Airway remodeling …

The onset of chronic obstructive pulmonary disease (COPD) is heterogeneous, and current
approaches to define distinct disease phenotypes are lacking. In addition to clinical …

Background Some people have characteristics of both asthma and COPD (asthma-COPD
overlap), and evidence suggests they experience worse outcomes than those with either …

Chronic obstructive pulmonary disease (COPD) is an increasing and major global health
problem. COPD is also the third leading cause of death worldwide. Oxidative stress (OS) …