MicroRNAs (miRNAs) are single-stranded, non-coding RNA molecules that play important
roles in the development and functions of the brain. Extensive studies have revealed critical …

Neuroimaging is central to the quest for a biological foundation of psychiatric diagnosis but
so far has not yielded clinically relevant biomarkers for mental disorders. This review …

Major depression is a debilitating psychiatric illness that is typically associated with low
mood and anhedonia. Depression has a heritable component that has remained difficult to …

Obsessive-compulsive disorder (OCD) is a common, debilitating neuropsychiatric illness
with complex genetic etiology. The International OCD Foundation Genetics Collaborative …

After decades of research aimed at elucidating the pathophysiology and etiology of
schizophrenia, it has become increasingly apparent that it is an illness knowing few …

Abstract The Genetics Core of the Alzheimer's Disease Neuroimaging Initiative (ADNI),
formally established in 2009, aims to provide resources and facilitate research related to …

Abstract The Function Biomedical Informatics Research Network (FBIRN) developed
methods and tools for conducting multi-scanner functional magnetic resonance imaging …

Although our knowledge of the pathophysiology of schizophrenia has increased, treatments
for this devastating illness remain inadequate. Here, we critically assess rodent models and …

Neural circuits consist of distinct neuronal cell types connected in specific patterns. The
specificity of these connections is achieved in a series of sequential developmental steps …

Small Rho family GTPases are important regulators of cellular traffic. Emerging evidence
now implicates Rac1 and Rac-dependent actin reorganisation in insulin-induced recruitment …