Health economic models rely on data from trials to project the risk of events (eg, death) over
time beyond the span of the available data. Parametric survival analysis methods can be …

Major liver resections and partial orthotopic liver transplantation (OLT) have become
established procedures in liver surgery; for many patients, these techniques offer the only …

Background. Treatment switching commonly occurs in clinical trials of novel interventions in
the advanced or metastatic cancer setting. However, methods to adjust for switching have …

Colorectal cancer (CRC) is still the third most common cancer in the world with a limited
prognosis due to the chemoresistance of CRC cells to 5‐fluorouracil (5‐FU)‐based …

Colorectal cancer is the third most common malignancy in the United States. Modest
advances with therapeutic approaches that include oxaliplatin (l-OHP) have brought the …

Background In peritoneal surface disease, accumulation of malignant ascites represents a
difficult problem to treat, with adverse impact on quality of life. The role of cytoreductive …

Background Transarterial liver-directed therapies are currently not recommended as a
standard treatment for colorectal liver metastases. Transarterial chemoembolization (TACE) …

Cost-effectiveness analysis may be applied to the full range of interventions that make up a
cancer service, including screening programmes and early treatments, diagnostic test and …

Aims Oxaliplatin (l-OHP) is a key drug in therapeutic regimens for metastatic or advanced-
stage colorectal cancer, but causes peripheral neuropathy as a dose-limiting adverse effect …

Inhibitors of thymidylate synthase (TS) play an essential role in the pharmacological
management of several tumors. Two antifolates, Raltitrexed and Pemetrexed, are licensed …