Germline apoptosis shares with somatic apoptosis a reliance on key components of the core
apoptotic machinery, including CED-3 and CED-4. However, germline apoptosis differs from …

DNA must be accurately copied and propagated from one cell division to the next, and from
one generation to the next. To ensure the faithful transmission of the genome, a plethora of …

The incorporation and creation of modified nucleobases in DNA have profound effects on
genome function. We describe methods for mapping positions and local content of modified …

In response to genotoxic insults, cells activate DNA damage response pathways that either
stimulate transient cell cycle arrest and DNA repair or induce apoptosis. The Caenorhabditis …

Base-excision repair and control of nucleotide pools safe-guard against permanent uracil
accumulation in DNA relying on two key enzymes: uracil–DNA glycosylase and dUTPase …

Exogenous and endogenous damage to the DNA is inevitable. Several DNA repair
pathways including base excision, nucleotide excision, mismatch, homologous and non …

The various symptoms associated with hereditary defects in the DNA damage response
(DDR), which range from developmental and neurological abnormalities and …

Cellular responses to DNA damage involve distinct DNA repair pathways, such as mismatch
repair (MMR) and base excision repair (BER). Using Caenorhabditis elegans as a model …

Transfer of phage-related pathogenicity islands of Staphylococcus aureus (SaPI-s) was
recently reported to be activated by helper phage dUTPases. This is a novel function for …

Fine-tuned regulation of the cellular nucleotide pools is indispensable for faithful replication
of Deoxyribonucleic Acid (DNA). The genetic information is also safeguarded by DNA …