Homocysteine metabolism gene polymorphisms (MTHFR C677T, MTHFR A1298C, MTR A2756G and MTRR A66G) jointly elevate the risk of folate deficiency

WX Li, SX Dai, JJ Zheng, JQ Liu, JF Huang - Nutrients, 2015 - mdpi.com
Folate deficiency is strongly associated with cardiovascular disease. We aimed to explore
the joint effect of the methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C …

Joint associations of folate, homocysteine and MTHFR, MTR and MTRR gene polymorphisms with dyslipidemia in a Chinese hypertensive population: a cross …

WX Li, WW Lv, SX Dai, ML Pan, JF Huang - Lipids in Health and Disease, 2015 - Springer
Background Dyslipidemia is a well-established risk factor for cardiovascular disease. Serum
lipids were affected by several gene polymorphisms, folate, homocysteine and other …

Association of C677T transition of the human methylenetetrahydrofolate reductase (MTHFR) gene with male infertility

M Karimian, AH Colagar - Reproduction, Fertility and …, 2016 - CSIRO Publishing
The human methylenetetrahydrofolate reductase (MTHFR) gene encodes one of the key
enzymes in folate metabolism. This gene is located on chromosome 1 (1p36. 3), which has …

The role of single-nucleotide polymorphisms in the function of candidate tumor suppressor ALDH1L1

SA Krupenko, DA Horita - Frontiers in Genetics, 2019 - frontiersin.org
Folate (vitamin B9) is a common name for a group of coenzymes that function as carriers of
chemical moieties called one-carbon groups in numerous biochemical reactions. The …

Tagging SNPs in the MTHFR Gene and Risk of Ischemic Stroke in a Chinese Population

BS Zhou, GY Bu, M Li, BG Chang, YP Zhou - International journal of …, 2014 - mdpi.com
Stroke is currently the leading cause of functional impairments worldwide. Folate
supplementation is inversely associated with risk of ischemic stroke …

Novel approaches to investigate one-carbon metabolism and related B-vitamins in blood pressure

A McMahon, H McNulty, CF Hughes, JJ Strain, M Ward - nutrients, 2016 - mdpi.com
Hypertension, a major risk factor for heart disease and stroke, is the world's leading cause of
preventable, premature death. A common polymorphism (677C→ T) in the gene encoding …

[PDF][PDF] Folate deficiency and gene polymorphisms of MTHFR, MTR and MTRR elevate the hyperhomocysteinemia risk

WX Li, F Cheng, AJ Zhang, SX Dai, GH Li, WW Lv… - Clin Lab, 2017 - researchgate.net
We aimed to investigate the joint effect of homocysteine metabolism gene polymorphisms,
as well as the folate deficiency on the risk of HHcy in a Chinese hypertensive population …

MTHFR-Ala222Val and male infertility: a study in Iranian men, an updated meta-analysis and an in silico-analysis

H Nikzad, M Karimian, K Sareban… - Reproductive …, 2015 - Elsevier
Methylenetetrahydrofolate reductase (MTHFR) functions as a main regulatory enzyme in
folate metabolism. The association of MTHFR gene Ala222Val polymorphism with male …

Association of the methylenetetrahydrofolate reductase (MTHFR) gene variant C677T with serum homocysteine levels and the severity of ischaemic stroke: a case …

LW Huang, LL Li, J Li, XR Chen… - Journal of International …, 2022 - journals.sagepub.com
Objective To determine whether the methylenetetrahydrofolate reductase (MTHFR) C677T
gene polymorphism is linked to the risk of ischaemic stroke and circulating homocysteine …

Meta-analysis of the relationship between methylenetetrahydrofolate reductase C677T and A1298C polymorphism and venous thromboembolism in the Caucasian …

M Gao, N Feng, M Zhang, X Ti, X Zuo - Bioscience reports, 2020 - portlandpress.com
Recent years, it is a highly debated topic that whether methylenetetrahydrofolate reductase
(MTHFR) C677T polymorphism and A1298C polymorphism could increase susceptibility to …