Novel 4-(2-arylidenehydrazineyl) thienopyrimidine derivatives as anticancer EGFR inhibitors: Design, synthesis, biological evaluation, kinome selectivity and in silico …
HA Elsebaie, EA El-Bastawissy, KM Elberembally… - Bioorganic …, 2023 - Elsevier
The current study discovered fifteen new thieno [2, 3-d] pyrimidine derivatives with potential
anticancer action, including 5a-l, 6, and 7a-b. Results from the NCI screening revealed that …
anticancer action, including 5a-l, 6, and 7a-b. Results from the NCI screening revealed that …
Discovery of sulfonamide-tethered isatin derivatives as novel anticancer agents and VEGFR-2 inhibitors
In this work, new isatin-based sulphonamides (6a-i, 11a-c, 12a-c) were designed and
synthesised as potential dual VEGFR-2 and carbonic anhydrase inhibitors with anticancer …
synthesised as potential dual VEGFR-2 and carbonic anhydrase inhibitors with anticancer …
Recruitment of hexahydroquinoline as anticancer scaffold targeting inhibition of wild and mutants EGFR (EGFRWT, EGFRT790M, and EGFRL858R)
Hexahydroquinoline (HHQ) scaffold was constructed and recruited for development of new
series of anticancer agents. Thirty-two new compounds were synthesised where x-ray …
series of anticancer agents. Thirty-two new compounds were synthesised where x-ray …
Novel N-Arylmethyl-aniline/chalcone hybrids as potential VEGFR inhibitors: synthesis, biological evaluations, and molecular dynamic simulations
Significant advancements have been made in the domain of targeted anticancer therapy for
the management of malignancies in recent times. VEGFR-2 is characterised by its pivotal …
the management of malignancies in recent times. VEGFR-2 is characterised by its pivotal …
Pyrrolizine/indolizine-bearing (un) substituted isoindole moiety: design, synthesis, antiproliferative and MDR reversal activities, and in silico studies
AL AbdelSamad, MT El-Saadi, AM Gouda… - RSC …, 2023 - pubs.rsc.org
Two new series of pyrrolizine/indolizine derivative-bearing (un) substituted isoindole moiety
were designed and synthesized. The anticancer potential of the new compounds was …
were designed and synthesized. The anticancer potential of the new compounds was …
Discovery of new 1, 3-diphenylurea appended aryl pyridine derivatives as apoptosis inducers through c-MET and VEGFR-2 inhibition: design, synthesis, in vivo and in …
Interest has been generated in VEGFR-2 and c-MET as potential receptors for the treatment
of different malignancies. Using aryl pyridine derivatives with 1, 3-diphenylurea attached, a …
of different malignancies. Using aryl pyridine derivatives with 1, 3-diphenylurea attached, a …
Antibacterial and Antileishmanial Activity of 1, 4‐Dihydropyridine Derivatives
We have synthesized twenty‐three 1, 4‐dihydropyridine derivatives (1, 4‐DHPs) by using a
microwave‐assisted one‐pot multicomponent Hantzsch reaction and evaluated their …
microwave‐assisted one‐pot multicomponent Hantzsch reaction and evaluated their …
Oxidation process of 1, 4-dihydropyridine, 1, 4-dihydropyrimidine, and pyrrolo-1, 4-dihydropyrimidine: quantum chemical study
MO Shyshkina, SM Desenko - Structural Chemistry, 2024 - Springer
Abstract Derivatives of 1, 4-dihydropyridine, 1, 4-dihydropyrimidine, and its azolo analogs
possess a wide range of biological activity and are involved in cellular bioenergetics …
possess a wide range of biological activity and are involved in cellular bioenergetics …