p63-related signaling at a glance

ML Fisher, S Balinth, AA Mills - Journal of cell science, 2020 - journals.biologists.com
ABSTRACT p63 (also known as TP63) is a transcription factor of the p53 family, along with
p73. Multiple isoforms of p63 have been discovered and these have diverse functions …

Targeting neuropilin-1 interactions is a promising anti-tumor strategy

SD Liu, LP Zhong, J He, YX Zhao - Chinese Medical Journal, 2021 - mednexus.org
Neuropilins (NRP1 and NRP2) are multifunctional receptor proteins that are involved in
nerve, blood vessel, and tumor development. NRP1 was first found to be expressed in …

Highly Potent, Selective, Biostable, and Cell-Permeable Cyclic d-Peptide for Dual-Targeting Therapy of Lung Cancer

Y Zhou, Y Zou, M Yang, S Mei, X Liu… - Journal of the …, 2022 - ACS Publications
The application of peptide drugs in cancer therapy is impeded by their poor biostability and
weak cell permeability. Therefore, it is imperative to find biostable and cell-permeable …

[HTML][HTML] α2, 6 Sialylation mediated by ST6GAL1 promotes glioblastoma growth

GC Sajina, K Tuy, L Rickenbacker, R Jones… - JCI insight, 2022 - ncbi.nlm.nih.gov
One of the least-investigated areas of brain pathology research is glycosylation, which is a
critical regulator of cell surface protein structure and function. β-Galactoside α2, 6 …

Dual targeted nanoparticles for the codelivery of doxorubicin and siRNA cocktails to overcome ovarian cancer stem cells

L Chen, J Luo, J Zhang, S Wang, Y Sun, Q Liu… - International Journal of …, 2023 - mdpi.com
Most anticancer treatments only induce the death of ordinary cancer cells, while cancer stem
cells (CSCs) in the quiescent phase of cell division are difficult to kill, which eventually leads …

HIF-1α promoted vasculogenic mimicry formation in lung adenocarcinoma through NRP1 upregulation in the hypoxic tumor microenvironment

R Fu, W Du, Z Ding, Y Wang, Y Li, J Zhu, Y Zeng… - Cell death & …, 2021 - nature.com
Neovascularization is a key factor that contributes to tumor metastasis, and vasculogenic
mimicry (VM) is an important form of neovascularization found in highly invasive tumors …

OLFML3, as a potential predictor of prognosis and therapeutic target for glioma, is closely related to immune cell infiltration

S Qu, C Huang, T Zhu, K Wang, H Zhang, L Wang… - View, 2023 - Wiley Online Library
The low response rate to immunosuppressant is mainly due to the lack of adequate
knowledge about the tumor microenvironment (TME) and screening biomarkers for gliomas …

[HTML][HTML] Histone deacetylase upregulation of neuropilin-1 in osteosarcoma is essential for pulmonary metastasis

N Nerlakanti, JJ McGuire, RT Bishop, MM Nasr, T Li… - Cancer Letters, 2024 - Elsevier
The lungs represent the most common site of metastasis for osteosarcoma (OS). Despite our
advances in developing targeted therapies for treating solid malignancies, broad acting …

Deciphering key regulators of Inonotus hispidus petroleum ether extract involved in anti-tumor through whole transcriptome and proteome analysis in H22 tumor …

Z Li, H Bao - Journal of Ethnopharmacology, 2022 - Elsevier
Abstract Ethnopharmacological relevance The mushroom Inonotus hispidus is traditional
Chinese medicine, which has been used to treat tumor illness for a long history in China …

Neuropilin (NRPs) related pathological conditions and their modulators

M Broz, A Kolarič, M Jukič, U Bren - International journal of molecular …, 2022 - mdpi.com
Neuropilin 1 (NRP1) represents one of the two homologous neuropilins (NRP, splice
variants of neuropilin 2 are the other) found in all vertebrates. It forms a transmembrane …