The cell cycle checkpoint proteins ataxia-telangiectasia-mutated-and-Rad3-related kinase
(ATR) and its major downstream effector checkpoint kinase 1 (CHK1) prevent the entry of …

Targeting the DNA damage response (DDR) is a new therapeutic approach in cancer that
shows great promise for tumour selectivity. Key components of the DDR are the ataxia …

Mammalian development, adult tissue homeostasis and the avoidance of severe diseases
including cancer require a properly orchestrated cell cycle, as well as error-free genome …

The FOXO3 and FOXM1 forkhead box transcription factors, functioning downstream of the
essential PI3K-Akt, Ras-ERK and JNK/p38MAPK signalling cascades, are crucial for cell …

Background and aims Continuing recalcitrance to therapy cements pancreatic cancer (PC)
as the most lethal malignancy, which is set to become the second leading cause of cancer …

Background Chemo-resistance is one of the major challenges in the therapy of small cell
lung cancer (SCLC). Multiple mechanisms are thought to be involved in chemo-resistance …

Background p53 plays a key role in the DNA repair process and response to ionising
radiation. We sought to determine the clinical phenotype of TP53 mutations and p53 …

Aims A major obstacle for effective cancer treatment by radiation therapy is the development
of radio-resistance and identification of underlying mechanisms and activated pathways will …

There is currently a lack of precise predictive biomarkers for patient selection in clinical trials
of inhibitors targeting replication stress (RS) response proteins ATR and CHK1. The …

Breast cancer has an extremely high incidence in women, and its morbidity and mortality
rank first among female tumors. With the increasing development of molecular biology and …