Control of IFN-γ-secreting T helper (Th) 1 cells prevents autoimmunity and
immunopathology during infection. IL-10-mediated suppression of Th1 cells is achieved not …

The current state-of-the-art tests for infection with Mycobacterium tuberculosis–the IFN-γ
release assays–rely on accurate measurement of the cytokine IFN-γ. Many other potential …

The ubiquitin-proteasome system degrades most intracellular proteins, including misfolded
proteins. Proteasome functional insufficiency (PFI) has been observed in proteinopathies …

Background The postnatal period is a critical time window during which inflammatory events
have significant and enduring effects on the brain, and as a consequence, induce alterations …

Cognitive impairment is one of the most frequent symptoms in patients with multiple
sclerosis (MS) but its underlying mechanisms are poorly understood. A number of …

The principal function of the proteasome is targeted degradation of intracellular proteins.
Proteasome dysfunction has been observed in experimental cardiomyopathies and …

The programmed cell death 1 (PD-1) receptor plays a major role in regulating T cell
activation. Our aim was to determine how inflammation influences PD-1-mediated T cell …

Abstract Context: The fruits of Aronia melanocarpa Elliot (Rosaceae),(black chokeberry), and
Sambucus nigra L.(Caprifoliaceae), elderberries are rich in anthocyanins. Many studies …

Triggering receptor expressed on myeloid cells 2 (TREM-2) is a modulator of pattern
recognition receptors on innate immune cells that regulates the inflammatory response …

Ets-1 is a transcription factor that is highly expressed within lymphoid cells, where it is known
to control their differentiation, survival and proliferation. Ets-1 is also expressed in other cell …