The distinct prion-like domains (PrLDs) of FUS and TDP-43, modulate phase transitions that
result in condensates with a range of material states. These assemblies are implicated in …

Solid-like protein deposits found in aged and diseased human brains have revealed a
relationship between insoluble protein accumulations and the resulting deficits in neurologic …

Nuclear clearance and cytoplasmic mislocalization of the essential RNA binding protein,
TDP-43, is a pathologic hallmark of amyotrophic lateral sclerosis, frontotemporal dementia …

RNA binding proteins (RBPs) are a large and diverse class of proteins that regulate all
aspects of RNA biology. As RBP dysregulation has been implicated in a number of human …

Neurodegenerative diseases represent a formidable challenge to global health. As
advances in other areas of medicine grant healthy living into later decades of life, aging …

A common feature of adult-onset neurodegenerative diseases is the presence of
characteristic pathological accumulations of specific proteins. These pathological protein …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with no cure or
effective treatment in which TAR DNA Binding Protein of 43 kDa (TDP-43) abnormally …

Transactive response DNA binding protein 43 kDa (TDP-43) was discovered in 2001 as a
cellular factor capable to inhibit HIV-1 gene expression. Successively, it was brought to new …

Pathogenic changes to TAR DNA-binding protein 43 (TDP-43) leading to alteration of its
homeostasis are a common feature shared by several progressive neurodegenerative …

Tar DNA binding (TDP)-43 proteinopathy, typically described as cytoplasmic accumulation
of highly modified and misfolded TDP-43 molecules, is characteristic of several …