Chronic venous disease (CVD) is a multifactorial condition affecting an important
percentage of the global population. It ranges from mild clinical signs, such as …

Stroke, a leading cause of long-term disability and death worldwide, has a heritable
component. Recent gene discovery efforts have expanded the number of known single …

Cells sense their environment and adapt to it by fine-tuning their transcriptome. Wired into
this network of gene expression control are mechanisms to compensate for gene dosage …

Cancer evolution determines molecular and morphologic intratumor heterogeneity and
challenges the design of effective treatments. In lung adenocarcinoma, disease progression …

Rationale: Idiopathic pulmonary fibrosis (IPF) is an untreatable and often fatal lung disease
that is increasing in prevalence and is caused by complex interactions between genetic and …

Mutations play a crucial role in evolution as they provide the genetic variation that allows
evolutionary change. Although some mutations in regulatory elements or coding regions can …

Neural progenitors alter their output over time to generate different types of neurons and glia
in specific chronological sequences, but this process remains poorly understood in …

The nucleosome remodeling and deacetylase (NuRD) complex is one of the central
chromatin remodeling complexes that mediates gene repression. NuRD is essential for …

Varicose veins of lower extremities (VVs) are a common multifactorial vascular disease.
Genetic factors underlying VVs development remain largely unknown. Here we report the …

The precise regulation of blood-brain barrier (BBB) permeability for immune cells and blood-
borne substances is essential to maintain brain homeostasis. Sphingosine-1-phosphate …