For nearly 50 years the proximal tubule (PT) has been known to reabsorb, process, and
either catabolize or transcytose albumin from the glomerular filtrate. Innovative techniques …

Serum albumin concentration (CP) is a remarkably strong prognostic indicator of morbidity
and mortality in both sick and seemingly healthy subjects. Surprisingly, the specifics of the …

Recent data highlight the role of the proximal tubule (PT) in reabsorbing, processing, and
transcytosing urinary albumin from the glomerular filtrate. Innovative techniques and …

Injury to podocytes is considered a major contributor to diabetic kidney disease: their loss
causes proteinuria and progressive glomerulosclerosis. Podocyte depletion may result from …

Inflammatory activation and/or dysfunction of the glomerular endothelium triggers proteinuria
in many systemic and localized vascular disorders. Among them are the thrombotic …

Background The kidney is considered to be a structurally stable organ with limited baseline
cellular turnover. Nevertheless, single cells must be constantly replaced to conserve the …

The amount of albumin filtered through the glomeruli and reabsorbed at the proximal tubules
in normal and in diabetic kidneys is debated. The megalin/cubilin complex mediates protein …

Intracellular calcium ([Ca2+] i) signaling mediates physiological and pathological processes
in multiple organs, including the renal podocyte; however, in vivo podocyte [Ca2+] i …

Hypertension-induced cardiovascular and renal damage can be mediated by activation of
the renin-angiotensin-aldosterone system. There are different factors beyond renin …

Albuminuria is a hallmark of kidney disease of various etiologies and usually caused by
deterioration of glomerular filtration barrier integrity. We recently showed that angiotensin II …