F Pociot, Å Lernmark - The Lancet, 2016 - thelancet.com
Type 1 diabetes is diagnosed at the end of a prodrome of β-cell autoimmunity. The disease is most likely triggered at an early age by autoantibodies primarily directed against insulin or …
Type 1 diabetes mellitus (T1DM) results from the destruction of pancreatic β-cells that is mediated by the immune system. Multiple genetic and environmental factors found in …
Type 1 diabetes mellitus (T1DM) results from the autoimmune destruction of β cells of the endocrine pancreas. Pathogenesis of T1DM is different from that of type 2 diabetes mellitus …
K Liao, J Xu, W Yang, X You, Q Zhong, X Wang - Molecular immunology, 2018 - Elsevier
Long non-coding RNA (lncRNA) is a non-coding RNA which lacks a complete open reading frame (ORF) and plays an important role in biological processes such as cell proliferation …
X He, C Ou, Y Xiao, Q Han, H Li, S Zhou - Oncotarget, 2017 - ncbi.nlm.nih.gov
Abstract Long non-coding RNAs (LncRNAs) are a class of endogenous RNA molecules, which have a transcribing length of over 200 nt, lack a complete functional open reading …
Type 1 diabetes (T1D) is a chronic immune-mediated disease resulting from the selective destruction of the insulin-producing pancreatic islet β-cells. Susceptibility to the disease is …
Z Li, X Li, C Jiang, W Qian, G Tse, MTV Chan… - Cell …, 2018 - Wiley Online Library
Rheumatoid arthritis, a disabling autoimmune disease, is associated with altered gene expression in circulating immune cells and synovial tissues. Accumulating evidence has …
After being long considered as “junk” in the human genome, non-coding RNAs (ncRNAs) currently represent one of the newest frontiers in cardiovascular disease (CVD) since they …
L López–Noriega, GA Rutter - Frontiers in Endocrinology, 2021 - frontiersin.org
Numerous studies have sought to decipher the genetic and other mechanisms contributing to β-cell loss and dysfunction in diabetes mellitus. However, we have yet to fully understand …