Deconstructing a syndrome: genomic insights into PCOS causal mechanisms and classification

M Dapas, A Dunaif - Endocrine reviews, 2022 - academic.oup.com
Polycystic ovary syndrome (PCOS) is among the most common disorders in women of
reproductive age, affecting up to 15% worldwide, depending on the diagnostic criteria …

Genetic risk factors for type 1 diabetes

F Pociot, Å Lernmark - The Lancet, 2016 - thelancet.com
Type 1 diabetes is diagnosed at the end of a prodrome of β-cell autoimmunity. The disease
is most likely triggered at an early age by autoantibodies primarily directed against insulin or …

The heterogeneous pathogenesis of type 1 diabetes mellitus

J Ilonen, J Lempainen, R Veijola - Nature Reviews Endocrinology, 2019 - nature.com
Type 1 diabetes mellitus (T1DM) results from the destruction of pancreatic β-cells that is
mediated by the immune system. Multiple genetic and environmental factors found in …

On type 1 diabetes mellitus pathogenesis

SA Paschou, N Papadopoulou-Marketou… - Endocrine …, 2018 - ec.bioscientifica.com
Type 1 diabetes mellitus (T1DM) results from the autoimmune destruction of β cells of the
endocrine pancreas. Pathogenesis of T1DM is different from that of type 2 diabetes mellitus …

The research progress of LncRNA involved in the regulation of inflammatory diseases

K Liao, J Xu, W Yang, X You, Q Zhong, X Wang - Molecular immunology, 2018 - Elsevier
Long non-coding RNA (lncRNA) is a non-coding RNA which lacks a complete open reading
frame (ORF) and plays an important role in biological processes such as cell proliferation …

[HTML][HTML] LncRNAs: key players and novel insights into diabetes mellitus

X He, C Ou, Y Xiao, Q Han, H Li, S Zhou - Oncotarget, 2017 - ncbi.nlm.nih.gov
Abstract Long non-coding RNAs (LncRNAs) are a class of endogenous RNA molecules,
which have a transcribing length of over 200 nt, lack a complete functional open reading …

Type 1 diabetes candidate genes linked to pancreatic islet cell inflammation and beta-cell apoptosis

J Størling, F Pociot - Genes, 2017 - mdpi.com
Type 1 diabetes (T1D) is a chronic immune-mediated disease resulting from the selective
destruction of the insulin-producing pancreatic islet β-cells. Susceptibility to the disease is …

Long non‐coding RNA s in rheumatoid arthritis

Z Li, X Li, C Jiang, W Qian, G Tse, MTV Chan… - Cell …, 2018 - Wiley Online Library
Rheumatoid arthritis, a disabling autoimmune disease, is associated with altered gene
expression in circulating immune cells and synovial tissues. Accumulating evidence has …

Deciphering non-coding RNAs in cardiovascular health and disease

A Das, A Samidurai, FN Salloum - Frontiers in cardiovascular …, 2018 - frontiersin.org
After being long considered as “junk” in the human genome, non-coding RNAs (ncRNAs)
currently represent one of the newest frontiers in cardiovascular disease (CVD) since they …

Long non-coding RNAs as key modulators of pancreatic β-cell mass and function

L López–Noriega, GA Rutter - Frontiers in Endocrinology, 2021 - frontiersin.org
Numerous studies have sought to decipher the genetic and other mechanisms contributing
to β-cell loss and dysfunction in diabetes mellitus. However, we have yet to fully understand …