Defective monocyte oxidative burst predicts infection in alcoholic hepatitis and is associated with reduced expression of NADPH oxidase

N Vergis, W Khamri, K Beale, F Sadiq, MO Aletrari… - Gut, 2017 - gut.bmj.com
Objective In order to explain the increased susceptibility to serious infection in alcoholic
hepatitis, we evaluated monocyte phagocytosis, aberrations of associated signalling …

Establishing a model composed of immune-related gene-modules to predict tumor immunotherapy response

D Fu, X Weng, Y Su, B Hong, A Zhao, J Lin - Scientific Reports, 2024 - nature.com
At present, tumor immunotherapy has been widely applied to treat various cancers.
However, the accuracy of predicting treatment efficacy has not yet achieved a significant …

Deciphering the Role of Circadian Clock in Inflammatory Response and Immune Disorders Using Model Checking and Petri Nets

HU Rahman, J Ahmad, A Akhmediyarova… - IEEE …, 2024 - ieeexplore.ieee.org
Circadian rhythms play a significant role to optimize immunity and combat infections. Any
disturbance of the circadian clock, which is caused by environmental cues or zeitgebers …

Modelling and analysis of the complement system signalling pathways: roles of C3, C5a and pro-inflammatory cytokines in SARS-CoV-2 infection

D Murad, RZ Paracha, MT Saeed, J Ahmad, A Mushtaq… - PeerJ, 2023 - peerj.com
The complement system is an essential part of innate immunity. It is activated by invading
pathogens causing inflammation, opsonization, and lysis via complement anaphylatoxins …

Formal modeling and analysis of the hexosamine biosynthetic pathway: role of O-linked N-acetylglucosamine transferase in oncogenesis and cancer progression

MT Saeed, J Ahmad, S Kanwal, AN Holowatyj… - PeerJ, 2016 - peerj.com
The alteration of glucose metabolism, through increased uptake of glucose and glutamine
addiction, is essential to cancer cell growth and invasion. Increased flux of glucose through …

Static Analysis of Dengue Biological Regulatory Network's

A Khan, S Ahmad, B Tahira, A Khalid - Biological Sciences, 2023 - irrespub.com
Dengue is an acute viral illness caused by the RNA virus of the family Flaviviridae and
spread by Aedes mosquitoes. Intense dengue is a spreading cause of serious disease and …

Formal modeling and analysis of ER-α associated Biological Regulatory Network in breast cancer

S Khalid, R Hanif, SHK Tareen, A Siddiqa, Z Bibi… - PeerJ, 2016 - peerj.com
Background Breast cancer (BC) is one of the leading cause of death among females
worldwide. The increasing incidence of BC is due to various genetic and environmental …

Formal modeling of mTOR associated biological regulatory network reveals novel therapeutic strategy for the treatment of cancer

Z Bibi, J Ahmad, A Siddiqa, RZ Paracha… - Frontiers in …, 2017 - frontiersin.org
Cellular homeostasis is a continuous phenomenon that if compromised can lead to several
disorders including cancer. There is a need to understand the dynamics of cellular …

[PDF][PDF] The stability and Hopf bifurcation of the dengue fever model with time delay

J Guan, L Wu, M Chen, X Dong, H Tang… - italian journal of pure …, 2017 - ijpam.uniud.it
This paper studied the dengue fever model with time delay. This paper divided the time
delay into four cases:(1) т1= т2= 0,(2) т1= т, т2= 0,(3) т1= 0, т2= т,(4) т1= т, т2= т, and …

Incorporating time delays in process hitting framework for dynamical modeling of large biological regulatory networks

IA Sheikh, J Ahmad, M Magnin, O Roux - Frontiers in Physiology, 2019 - frontiersin.org
Modeling and simulation of molecular systems helps in understanding the behavioral
mechanism of biological regulation. Time delays in production and degradation of …