T memory stem (TSCM) cells are a rare subset of memory lymphocytes endowed with the
stem cell–like ability to self-renew and the multipotent capacity to reconstitute the entire …

Methods A comprehensive review of the English‐language publications was conducted. We
searched Ovid Medline, JSTOR and Scopus electronic databases with keyword …

Before initiation of antiretroviral therapy (ART), HIV-specific CD8+ T cells are dysfunctional
and short lived. To better understand the relationship between the HIV reservoir in CD4+ T …

Although many HIV cure strategies seek to expand HIV-specific CD8+ T cells to control the
virus, all are likely to fail if cellular exhaustion is not prevented. A loss in stem-like memory …

Summary Background Harnessing CD8+ T cell responses is being explored to achieve HIV
remission. Although HIV-specific CD8+ T cells become dysfunctional without treatment …

Adaptive immunity requires the generation of memory T cells from naive precursors selected
in the thymus. The key intermediaries in this process are stem cell-like memory T (T SCM) …

Memory T cells include T memory stem cells (TSCM) and central memory T cells (TCM).
Compared with effector memory T cells (TEM) and effector T cells (TEFF), they have better …

HIV-1–specific broadly neutralizing antibodies (bnAbs) typically develop in individuals with
continuous high-level viral replication and increased immune activation, conditions that …

Stem cell-like memory T cells (Tscm), are a newly defined memory T cell subset with
characteristics of long life span, consistent self-renewing, rapid differentiation into effector T …

The emerging HIV-1 resistance epidemic is threatening the impressive global advances in
HIV-1 infection treatment and prevention achieved in the last decade. Next-generation …