The function of G protein-coupled receptors (GPCRs) which represent the largest class of
both human membrane proteins and drug targets depends critically on their ability to …

Organisms of all domains of life use photoreceptor proteins to sense and respond to light.
The light-sensitivity of photoreceptor proteins arises from bound chromophores such as …

Class A G-protein-coupled receptors (GPCRs) influence virtually every aspect of human
physiology. Understanding receptor activation mechanism is critical for discovering novel …

G-protein-coupled receptors (GPCRs) are physiologically important membrane proteins that
sense signalling molecules such as hormones and neurotransmitters, and are the targets of …

G protein-coupled receptors (GPCRs) are responsible for the majority of cellular responses
to hormones and neurotransmitters as well as the senses of sight, olfaction and taste. The …

G-protein-coupled receptors (GPCRs) can modulate diverse signaling pathways, often in a
ligand-specific manner. The full range of functionally relevant GPCR conformations is poorly …

Conformational selection and induced fit are two prevailing mechanisms, to explain the
molecular basis for ligand-based activation of receptors. G-protein-coupled receptors are the …

The light sensor of vertebrate scotopic (low-light) vision, rhodopsin, is a G-protein-coupled
receptor comprising a polypeptide chain with bound chromophore, 11-cis-retinal, that …

Chemokine receptors are critical regulators of cell migration in the context of immune
surveillance, inflammation, and development. The G protein–coupled chemokine receptor …

Genetically encoded, single-component optogenetic tools have made a significant impact on
neuroscience, enabling specific modulation of selected cells within complex neural tissues …