Viewing metabolism through the lens of exercise biology has proven an accessible and
practical strategy to gain new insights into local and systemic metabolic regulation. Recent …

Mechanisms underlying mechanical overload-induced skeletal muscle hypertrophy have
been extensively researched since the landmark report by Morpurgo (1897) of “work …

The progressive loss of skeletal muscle mass and concomitant reduction in contractile
strength plays a central role in frailty syndrome. Age-related neuronal impairments are …

For centuries, regular exercise has been acknowledged as a potent stimulus to promote,
maintain, and restore healthy functioning of nearly every physiological system of the human …

Human skeletal muscle characteristics such as fiber type composition, fiber size, and
myonuclear content are widely studied in clinical and sports-related contexts. Being aware …

Most cells in the body are mononuclear whereas skeletal muscle fibres are uniquely
multinuclear. The nuclei of muscle fibres (myonuclei) are usually situated peripherally which …

Exercise promotes functional improvements in aged tissues, but the extent to which it
simulates partial molecular reprogramming is unknown. Using transcriptome profiling from …

Muscle atrophy is a common complication of many chronic diseases including heart failure,
cancer cachexia, aging, etc. Unhealthy habits and usage of hormones such as …

With the expansion of the aging population, age-associated sarcopenia (AAS) has become
a severe clinical disease of the elderly and a key challenge for healthy aging. Regrettably …

Many neuromuscular disorders can have a differential impact on a specific myofibre type,
forming the central premise of this review. The many different skeletal muscles in mammals …