Salmonella enterica infections are common causes of bloodstream infection in low-resource
areas, where they may be difficult to distinguish from other febrile illnesses and may be …

Salmonella enterica serovar Typhi, the cause of typhoid, is host restricted to humans. S.
Typhi has a monophyletic population structure, indicating that typhoid in humans is a …

Clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-
associated (Cas) genes are present in many bacterial and archaeal genomes. Since the …

Enteric fever is a life-threatening systemic febrile disease caused by Salmonella enterica
serovars Typhi and Paratyphi (S. Typhi and S. Paratyphi). Unfortunately, the burden of the …

Reverse vaccinology (RV), the first application of genomic technologies in vaccine research,
represented a major revolution in the process of discovering novel vaccines. By determining …

To revitalize the antibiotic pipeline, it is critical to identify and validate new antimicrobial
targets. In Mycobacteria tuberculosis and Francisella tularensis, biotin biosynthesis is a key …

Reverse vaccinology defines the process of antigen discovery starting from genome
information. From its first application to Neisseria meningitidis group B, this approach has …

Background Rapid and reliable diagnostic assays for enteric (typhoid and paratyphoid) fever
are urgently needed. We report the characterization of novel approach utilizing lymphocyte …

Background Iron is a key pathogenic determinant of many infectious diseases. Hepcidin, the
hormone responsible for governing systemic iron homeostasis, is widely hypothesized to …

Introduction Salmonella is responsible for causing enteric fever, septicemia, and
gastroenteritis in humans. Due to high disease burden and emergence of multi-and …