Resazurin (RZ) is a low-toxic redox-sensitive indicator that is weakly fluorescent but
becomes strongly fluorescent after reducing to resorufin (RS). The focal point attracting the …

This study evaluated cross-resistance of Mycobacterium tuberculosis strains to ofloxacin,
moxifloxacin, and gatifloxacin and investigated the presence of mutations in gyrA and gyrB …

Objectives To develop simple, rapid, low-cost and robust assays for screening drugs against
dormant and actively growing mycobacteria. Methods Actively growing aerobic and hypoxia …

Global tuberculosis (TB) eradication is undermined by increasing prevalence of emerging
resistance to available drugs, fuelling ongoing demand for more complex diagnostic and …

ABSTRACT Bedaquiline Drug Resistance Emergence Assessment in Multidrug-resistant
tuberculosis (MDR-TB)(DREAM) was a 5-year (2015 to 2019) phenotypic drug resistance …

With the emergence of multidrug-resistant tuberculosis (MDR-TB), the need for rapid drug
susceptibility testing (DST) is felt globally. National tuberculosis control programmes (NTPs) …

Background Many developed countries need a diagnostic test that is accurate, rapid, and
economical in detecting multidrug-resistant tuberculosis. This study aims to evaluate …

Resazurin (or Alamar Blue) is a poorly fluorescent dye. During the cellular reduction of
resazurin, its highly fluorescent product resorufin is formed. Resazurin assay is a commonly …

New genotypic and phenotypic methods for rapid diagnosis and detection of drug resistance
have been developed and tested both in M. tuberculosis strains as well as in clinical …

Tuberculosis still represents a major public health problem, especially in low-resource
countries where the burden of the disease is more important. Multidrug-resistant and …