Clinical aspects of snakebite envenoming and its treatment in low-resource settings

DA Warrell, DJ Williams - The Lancet, 2023 - thelancet.com
There is increasing recognition of the public health importance of snakebite envenoming.
Worldwide annual incidence is likely to be 5 million bites, with mortality exceeding 150 000 …

History of envenoming therapy and current perspectives

MB Pucca, FA Cerni, R Janke… - Frontiers in …, 2019 - frontiersin.org
Each year, millions of humans fall victim to animal envenomings, which may either be
deadly or cause permanent disability to the effected individuals. The Nobel Prize-winning …

[PDF][PDF] Antivenomics and its role in enhancing cobra envenomation treatments: A review of current practices and future prospects

I Karunarathna, K De Alvis, P Gunasena… - 2024 - researchgate.net
The King Cobra (Ophiophagus hannah) holds cultural significance and is one of the most
medically important venomous snakes worldwide. Envenomation by King Cobras often …

Discovery and optimization of a broadly-neutralizing human monoclonal antibody against long-chain α-neurotoxins from snakes

L Ledsgaard, J Wade, TP Jenkins, K Boddum… - Nature …, 2023 - nature.com
Snakebite envenoming continues to claim many lives across the globe, necessitating the
development of improved therapies. To this end, broadly-neutralizing human monoclonal …

[PDF][PDF] Innovative approaches to neutralizing cobra venom: Advances in antivenomics and recombinant antivenoms

I Karunarathna, K De Alvis, P Gunasena… - 2024 - researchgate.net
The King Cobra (Ophiophagus hannah) holds cultural significance and is one of the most
medically important venomous snakes worldwide. Envenomation by King Cobras often …

Antibody-dependent enhancement of toxicity of myotoxin II from Bothrops asper

CV Sørensen, J Fernández, AC Adams… - Nature …, 2024 - nature.com
Improved therapies are needed against snakebite envenoming, which kills and permanently
disables thousands of people each year. Recently developed neutralizing monoclonal …

Unveiling the functional epitopes of cobra venom cytotoxin by immunoinformatics and epitope-omic analyses

JJ Hiu, JKY Fung, HS Tan, MKK Yap - Scientific Reports, 2023 - nature.com
Approximate 70% of cobra venom is composed of cytotoxin (CTX), which is responsible for
the dermonecrotic symptoms of cobra envenomation. However, CTX is generally low in …

Biosynthetic oligoclonal antivenom (BOA) for snakebite and next-generation treatments for snakebite victims

RM Kini, SS Sidhu, AH Laustsen - Toxins, 2018 - mdpi.com
Snakebite envenoming is a neglected tropical disease that each year claims the lives of
80,000–140,000 victims worldwide. The only effective treatment against envenoming …

Innovative immunization strategies for antivenom development

E Bermúdez-Méndez, A Fuglsang-Madsen, S Føns… - Toxins, 2018 - mdpi.com
Snakes, scorpions, and spiders are venomous animals that pose a threat to human health,
and severe envenomings from the bites or stings of these animals must be treated with …

[HTML][HTML] Clinical management of snakebite envenoming: future perspectives

M Hamza, C Knudsen, CA Gnanathasan, W Monteiro… - Toxicon: X, 2021 - Elsevier
Snakebite envenoming is a major cause of morbidity and mortality in rural communities
throughout the tropics. Generally, the main clinical features of snakebites are local swelling …