Cellular function and molecular structure of ecto-nucleotidases
Ecto-nucleotidases play a pivotal role in purinergic signal transmission. They hydrolyze
extracellular nucleotides and thus can control their availability at purinergic P2 receptors …
extracellular nucleotides and thus can control their availability at purinergic P2 receptors …
Autotaxin in pathophysiology and pulmonary fibrosis
I Ninou, C Magkrioti, V Aidinis - Frontiers in medicine, 2018 - frontiersin.org
Lysophospholipid signaling is emerging as a druggable regulator of pathophysiological
responses, and especially fibrosis, exemplified by the relative ongoing clinical trials in …
responses, and especially fibrosis, exemplified by the relative ongoing clinical trials in …
The expression regulation and biological function of autotaxin
X Zhang, M Li, N Yin, J Zhang - Cells, 2021 - mdpi.com
Autotaxin (ATX) is a secreted glycoprotein and functions as a key enzyme to produce
extracellular lysophosphatidic acid (LPA). LPA interacts with at least six G protein-coupled …
extracellular lysophosphatidic acid (LPA). LPA interacts with at least six G protein-coupled …
The effect of individual N-glycans on enzyme activity
D Skropeta - Bioorganic & medicinal chemistry, 2009 - Elsevier
In a series of investigations, N-glycosylation has proven to be a key determinant of enzyme
secretion, activity, binding affinity and substrate specificity, enabling a protein to fine-tune its …
secretion, activity, binding affinity and substrate specificity, enabling a protein to fine-tune its …
Adipose-specific disruption of autotaxin enhances nutritional fattening and reduces plasma lysophosphatidic acid
R Dusaulcy, C Rancoule, S Grès, E Wanecq… - Journal of lipid …, 2011 - ASBMB
Autotaxin (ATX) is a secreted lysophospholipase D that generates the lipid mediator
lysophosphatidic acid (LPA). ATX is secreted by adipose tissue and its expression is …
lysophosphatidic acid (LPA). ATX is secreted by adipose tissue and its expression is …
Autotaxin, a secreted lysophospholipase D, as a promising therapeutic target in chronic inflammation and cancer
Autotaxin (ATX) is a member of the nucleotide pyrophosphatase/phosphodiesterase family
of ectoenzymes that hydrolyzes phosphodiester bonds of various nucleotides. It possesses …
of ectoenzymes that hydrolyzes phosphodiester bonds of various nucleotides. It possesses …
[HTML][HTML] Autotaxin–Lysophosphatidate axis: promoter of cancer development and possible therapeutic implications
C Laface, AD Ricci, S Vallarelli, C Ostuni… - International Journal of …, 2024 - mdpi.com
Autotaxin (ATX) is a member of the ectonucleotide pyrophosphate/phosphodiesterase
(ENPP) family; it is encoded by the ENPP2 gene. ATX is a secreted glycoprotein and …
(ENPP) family; it is encoded by the ENPP2 gene. ATX is a secreted glycoprotein and …
Autotaxin in breast cancer: role, epigenetic regulation and clinical implications
A Drosouni, M Panagopoulou, V Aidinis, E Chatzaki - Cancers, 2022 - mdpi.com
Simple Summary Autotaxin (ATX) has been linked with the pathogenesis of several cancers
and especially with breast cancer (BC). BC is one of the most common cancers among …
and especially with breast cancer (BC). BC is one of the most common cancers among …
Murine and human autotaxin α, β, and γ isoforms: gene organization, tissue distribution, and biochemical characterization
A Giganti, M Rodriguez, B Fould, N Moulharat… - Journal of Biological …, 2008 - ASBMB
Autotaxin is a type II ectonucleotide pyrophosphate phosphodiesterase enzyme. It has been
recently discovered that it also has a lysophospholipase D activity. This enzyme probably …
recently discovered that it also has a lysophospholipase D activity. This enzyme probably …
[HTML][HTML] Serum autotaxin levels are correlated with hepatic fibrosis and ballooning in patients with non-alcoholic fatty liver disease
AIM To examine the relationship between serum autotaxin (ATX) concentrations and
clinicopathological findings in non-alcoholic fatty liver disease (NAFLD) patients. METHODS …
clinicopathological findings in non-alcoholic fatty liver disease (NAFLD) patients. METHODS …