A deep dive into UV-based phototherapy: Mechanisms of action and emerging molecular targets in inflammation and cancer

PA Vieyra-Garcia, P Wolf - Pharmacology & therapeutics, 2021 - Elsevier
UV-based phototherapy (including psoralen plus UVA (PUVA), UVB and UVA1) has a long,
successful history in the management of numerous cutaneous disorders. Photoresponsive …

The evolving role of TRAFs in mediating inflammatory responses

B Dhillon, F Aleithan, Z Abdul-Sater… - Frontiers in …, 2019 - frontiersin.org
TRAFs [tumor necrosis factor (TNF) receptor associated factors] are a family of signaling
molecules that function downstream of multiple receptor signaling pathways and play a …

Aspergillus fumigatus Stimulates the NLRP3 Inflammasome through a Pathway Requiring ROS Production and the Syk Tyrosine Kinase

N Saïd-Sadier, E Padilla, G Langsley, DM Ojcius - PloS one, 2010 - journals.plos.org
Invasive aspergillosis (IA) is a life-threatening disease that occurs in immunodepressed
patients when infected with Aspergillus fumigatus. This fungus is the second most-common …

Vitamin D receptor inhibits NLRP3 activation by impeding its BRCC3-mediated deubiquitination

Z Rao, X Chen, J Wu, M Xiao, J Zhang… - Frontiers in …, 2019 - frontiersin.org
The NLRP3 inflammasome is a multiprotein oligomer responsible for activation of the
inflammatory response by promoting the maturation and secretion of the pro-inflammatory …

The oral microbiome: its role in health and in oral and systemic infections

FA Scannapieco - Clinical Microbiology Newsletter, 2013 - Elsevier
The oral cavity harbors a rich and diverse microflora, which is mostly found within biofilms
attached to the various soft-and hard-tissue surfaces. Recent studies using molecular …

Biochanin A protects lipopolysaccharide/D-galactosamine-induced acute liver injury in mice by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome …

X Liu, T Wang, X Liu, L Cai, J Qi, P Zhang… - International …, 2016 - Elsevier
Biochanin A, an isoflavone existed in red clover and peanuts, has been reported to possess
a wide spectrum of pharmacological activities, such as anti-inflammatory and antioxidant …

Chlamydia pneumoniae: An Etiologic Agent for Late-Onset Dementia

BJ Balin, CJ Hammond, CS Little, ST Hingley… - Frontiers in aging …, 2018 - frontiersin.org
The disease known as late-onset Alzheimer's disease is a neurodegenerative condition
recognized as the single most commonform of senile dementia. The condition is sporadic …

Modulation of inflammasome activity by Porphyromonas gingivalis in periodontitis and associated systemic diseases

I Olsen, Ö Yilmaz - Journal of oral microbiology, 2016 - Taylor & Francis
Inflammasomes are large multiprotein complexes localized in the cytoplasm of the cell. They
are responsible for the maturation of pro-inflammatory cytokines such as interleukin-1β (IL …

[HTML][HTML] Role of extracellular nucleotides in the immune response against intracellular bacteria and protozoan parasites

R Coutinho-Silva, DM Ojcius - Microbes and Infection, 2012 - Elsevier
Extracellular nucleotides are danger signals involved in recognition and control of
intracellular pathogens. They are an important component of the innate immune response …

Influence of inflammasome NLRP3, and IL1B and IL2 gene polymorphisms in periodontitis susceptibility

JB de Alencar, JMV Zacarias, PY Tsuneto, VH Souza… - PloS one, 2020 - journals.plos.org
The pathogenesis of periodontitis (PD) involves several molecules of the immune system
that interact in a network to eliminate the periodontopathogens, yet, they contribute to …