Monoclonal antibody-based immunotherapy is now considered to be a main component of
cancer therapy, alongside surgery, radiation, and chemotherapy. Monoclonal antibodies …

Triple-negative breast cancer (TNBC) is characterised by poor outcomes and a historical
lack of targeted therapies. Dysregulation of signalling through the phosphoinositide 3 (PI3) …

Cancer stem cells (CSCs) represent a tumor subpopulation responsible for tumor metastasis
and resistance to chemo-and radiotherapy, ultimately leading to tumor relapse. As a …

Simple Summary Cancer is one of the hardest pathologies to fight, being one of the main
causes of death worldwide despite the constant development of novel therapeutic strategies …

Breast cancer is the most frequent type of malignancy in women worldwide, and drug
resistance to the available systemic therapies remains a major challenge. At the molecular …

PTEN is one of the most frequently inactivated tumor suppressor genes in cancer. Loss or
variation in PTEN gene/protein levels is commonly observed in a broad spectrum of human …

Epithelial–mesenchymal transition (EMT) programs play essential functions in normal
morphogenesis and organogenesis, including that occurring during mammary gland …

Vimentin, a kind of intermediate filament protein III in mesenchymal cells, has become a
highly researched topic around the world in recent years, as it holds complex biological …

The ability of breast cancer cells to transiently transition between epithelial and
mesenchymal states contributes to their metastatic potential. Therefore, driving tumor cells …

Triple negative breast cancer (TNBC) typically exhibits rapid progression, high mortality and
faster relapse rates relative to other breast cancer subtypes. In this report we examine the …