Infections with protozoan parasites are a major cause of disease and mortality in many
tropical countries of the world. Diseases caused by species of the genera Trypanosoma …

This review discusses the challenges of chemotherapy for human African trypanosomiasis
(HAT). The few drugs registered for use against the disease are unsatisfactory for a number …

Arsenicals were introduced as monotherapies for the treatment of human African
trypanosomiasis, or sleeping sickness, over 100 years ago. Toxicity has always been an …

The predominant mechanism of drug resistance in African trypanosomes is decreased drug
uptake due to loss-of-function mutations in the genes for the transporters that mediate drug …

Aquaglyceroporins (AQPs) transport water and glycerol and play important roles in drug-
uptake in pathogenic trypanosomatids. For example, AQP2 in the human-infectious African …

Background The induction of hepatic stellate cell (HSC) apoptosis has potential as a potent
strategy to diminish the progression of liver fibrosis. Previous studies have demonstrated the …

Trypanocidal sensitivity studies were conducted to assess the efficacy of Diminazene
diaceturate (Diminasan®) and Bis (aminoethylthio) 4-melaminophenylarsine …

We analyzed DNA eluted from FTA (Flinders Technology Associates) cards spotted with
blood from human African trypanosomiasis (HAT) patients admitted at Lwala Hospital in …

We carried out a baseline survey of cattle in Kaberamaido district, in the context of
controlling the domestic animal reservoir of Trypanosoma brucei rhodesiense human …

Resistance of trypanosomes to melarsoprol is ascribed to reduced uptake of the drug via the
P2 nucleoside transporter. The aim of this study was to look for evidence of drug resistance …