Antecedentes Esta la segunda actualización de una revisión publicada anteriormente en la
Biblioteca Cochrane (2015, primera actualización en 2017). La interleucina 5 (IL‐5) es la …

The human eosinophil has long been thought to favorably influence innate mucosal
immunity but at times has also been incriminated in disease pathophysiology. Research into …

Background Benralizumab is a humanised, afucosylated, anti-interleukin-5 receptor α
monoclonal antibody that induces direct, rapid, and nearly complete depletion of …

Background ANDHI was done to assess the efficacy of benralizumab, including onset of
effect and impact on health-related quality of life (HRQOL), exacerbation rate, lung function …

Background Eosinophilic gastritis and duodenitis are characterized by gastrointestinal
mucosal eosinophilia, chronic symptoms, impaired quality of life, and a lack of adequate …

Background Eosinophilia is associated with worsening asthma severity and decreased lung
function, with increased exacerbation frequency. We assessed the safety and efficacy of …

Background Persistent eosinophilic airway inflammation in asthma increases the risk of
exacerbations. In a phase 2b dose-ranging study, we aimed to assess the efficacy and …

The recognition that asthma is primarily an inflammatory disorder of the airways associated
with T helper type 2 (TH2) cell-dependent promotion of IgE production and recruitment of …

abstract Biologics have been a key component of severe asthma treatment, and there are
currently biologics available that target IgE, IL-5, IL-4/IL-13, and TSLP. Randomized …

The enigmatic eosinophil has emerged as an exciting component of the immune system,
involved in a plethora of homeostatic and inflammatory responses. Substantial progress has …