Mucosal delivery of therapeutic and prophylactic molecules using lactic acid bacteria

JM Wells, A Mercenier - Nature Reviews Microbiology, 2008 - nature.com
Studies of lactic acid bacteria (LAB) as delivery vehicles have focused mainly on the
development of mucosal vaccines, with much effort being devoted to the generation of …

Lactococci and lactobacilli as mucosal delivery vectors for therapeutic proteins and DNA vaccines

LG Bermúdez-Humarán, P Kharrat, JM Chatel… - Microbial cell …, 2011 - Springer
Abstract Food-grade Lactic Acid Bacteria (LAB) have been safely consumed for centuries by
humans in fermented foods. Thus, they are good candidates to develop novel oral vectors …

Lactic acid bacteria—20 years exploring their potential as live vectors for mucosal vaccination

A Wyszyńska, P Kobierecka, J Bardowski… - Applied microbiology …, 2015 - Springer
Lactic acid bacteria (LAB) are a diverse group of Gram-positive, nonsporulating, low G+ C
content bacteria. Many of them have been given generally regarded as safe status. Over the …

Display of recombinant proteins at the surface of lactic acid bacteria: strategies and applications

C Michon, P Langella, VGH Eijsink, G Mathiesen… - Microbial cell …, 2016 - Springer
Lactic acid bacteria (LAB) are promising vectors of choice to deliver active molecules to
mucosal tissues. They are recognized as safe by the World Health Organization and some …

Live bacterial vaccines–a review and identification of potential hazards

A Detmer, J Glenting - Microbial cell factories, 2006 - Springer
The use of live bacteria to induce an immune response to itself or to a carried vaccine
component is an attractive vaccine strategy. Advantages of live bacterial vaccines include …

Lactococcus lactis as a live vector: heterologous protein production and DNA delivery systems

DS Pontes, MSP De Azevedo, JM Chatel… - Protein expression and …, 2011 - Elsevier
Lactic acid bacteria (LAB), widely used in the food industry, are present in the intestine of
most animals, including humans. The potential use of these bacteria as mucosal delivery …

Mucosal vaccination and therapy with genetically modified lactic acid bacteria

J Wells - Annual review of food science and technology, 2011 - annualreviews.org
Lactic acid bacteria (LAB) have proved to be effective mucosal delivery vehicles that
overcome the problem of delivering functional proteins to the mucosal tissues. By the …

Oral immunization with live Lactococcus lactis expressing rotavirus VP8* subunit induces specific immune response in mice

B Marelli, AR Perez, C Banchio, D de Mendoza… - Journal of Virological …, 2011 - Elsevier
Rotaviruses are the major cause of worldwide infectious diarrhea in children and
vaccination is considered to be the most effective way to control these infections. The …

Lactococcus lactis as a cell factory for delivery of therapeutic proteins

M Bahey-El-Din, CGM Gahan, BT Griffin - Current gene therapy, 2010 - ingentaconnect.com
The food-grade bacterium Lactococcus lactis has been extensively investigated during the
last two decades as a delivery vector for therapeutic proteins, DNA and vaccine antigens …

Modern approaches in probiotics research to control foodborne pathogens

MAR Amalaradjou, AK Bhunia - Advances in food and nutrition research, 2012 - Elsevier
Foodborne illness is a serious public health concern. There are over 200 known microbial,
chemical, and physical agents that are known to cause foodborne illness. Efforts are made …