Metastasis is the cause of over 90% of cancer-related deaths. Cancer cells undergoing
metastasis can switch dynamically between different phenotypes, enabling them to adapt to …

During development, interactions between transcription factors control the specification of
different cell fates. The regulatory networks of genetic interactions often exhibit multiple …

The human adaptive immune system is a very complex network of different types of cells,
cytokines, and signaling molecules. This complex network makes it difficult to understand …

In a bacterial population, the cell-to-cell communication using chemical molecule as a signal
in order to perform a collective task is called as quorum sensing. This communicating …

Identifying the design principles of complex regulatory networks driving cellular decision-
making remains essential to decode embryonic development as well as enhance cellular …

Many cell-fate decisions during embryonic development are governed by a motif comprised
of two transcription factors (TFs) A and B that mutually inhibit each other and may self …

Synthetic circuits embedded in host cells compete with cellular processes for limited
intracellular resources. Here we show how funnelling of cellular resources, after global …

Gene regulatory networks (GRNs) are complex systems in which many genes regulate
mutually to adapt the cell state to environmental conditions. In addition to function, the GRNs …

Switch-like behaviours in biochemical networks are of fundamental significance in biological
signal processing, and exist as two distinct types: ultra-sensitivity and bistability. Here we …

We present a technique applicable in any dynamical framework to identify control-robust
subsets of an interacting system. These robust subsystems, which we call stable modules …