Microglia-mediated neuroinflammation: a potential target for the treatment of cardiovascular diseases

M Wang, W Pan, Y Xu, J Zhang, J Wan… - Journal of inflammation …, 2022 - Taylor & Francis
Microglia are tissue-resident macrophages of the central nervous system (CNS). In the CNS,
microglia play an important role in the monitoring and intervention of synaptic and neuron …

Gut microbiota in hypertension and atherosclerosis: a review

BJH Verhaar, A Prodan, M Nieuwdorp, M Muller - Nutrients, 2020 - mdpi.com
Gut microbiota and its metabolites such as short chain fatty acids (SCFA),
lipopolysaccharides (LPS), and trimethylamine-N-oxide (TMAO) impact cardiovascular …

The gut microbiota and the brain–gut–kidney axis in hypertension and chronic kidney disease

T Yang, EM Richards, CJ Pepine… - Nature Reviews …, 2018 - nature.com
Crosstalk between the gut microbiota and the host has attracted considerable attention
owing to its involvement in diverse diseases. Chronic kidney disease (CKD) is commonly …

Hypertension-linked pathophysiological alterations in the gut

MM Santisteban, Y Qi, J Zubcevic, S Kim… - Circulation …, 2017 - Am Heart Assoc
Rationale: Sympathetic nervous system control of inflammation plays a central role in
hypertension. The gut receives significant sympathetic innervation, is densely populated …

The immunology of hypertension

AE Norlander, MS Madhur, DG Harrison - Journal of Experimental …, 2018 - rupress.org
Although systemic hypertension affects a large proportion of the population, its etiology
remains poorly defined. Emerging evidence supports the concept that immune cells become …

Role of inflammatory chemokines in hypertension

TP Mikolajczyk, P Szczepaniak, F Vidler… - Pharmacology & …, 2021 - Elsevier
Hypertension is associated with immune cells activation and their migration into the kidney,
vasculature, heart and brain. These inflammatory mechanisms are critical for blood pressure …

Gut microbiome and neuroinflammation in hypertension

EM Richards, J Li, BR Stevens, CJ Pepine… - Circulation …, 2022 - Am Heart Assoc
Hypertension is a worldwide problem with major impacts on health including morbidity and
mortality, as well as consumption of health care resources. Nearly 50% of American adults …

Immune and inflammatory mechanisms in hypertension

TJ Guzik, R Nosalski, P Maffia… - Nature Reviews …, 2024 - nature.com
Hypertension is a global health problem, with> 1.3 billion individuals with high blood
pressure worldwide. In this Review, we present an inflammatory paradigm for hypertension …

C‐reactive protein as an effector molecule in Covid‐19 pathogenesis

JA Mosquera‐Sulbaran, A Pedreañez… - Reviews in medical …, 2021 - Wiley Online Library
The current pandemic caused by SARS‐CoV‐2 virus infection is known as Covid‐19
(coronavirus disease 2019). This disease can be asymptomatic or can affect multiple organ …

Prebiotics, probiotics, and acetate supplementation prevent hypertension in a model of obstructive sleep apnea

BP Ganesh, JW Nelson, JR Eskew, A Ganesan… - …, 2018 - Am Heart Assoc
Disruption of the gut microbiota, termed gut dysbiosis, has been described in animal models
of hypertension and hypertensive patients. We have shown that gut dysbiosis plays a causal …