Insertions and deletions: Computational methods, evolutionary dynamics, and biological applications

BD Redelings, I Holmes, G Lunter… - Molecular biology …, 2024 - academic.oup.com
Insertions and deletions constitute the second most important source of natural genomic
variation. Insertions and deletions make up to 25% of genomic variants in humans and are …

KINN: an alignment-free accurate phylogeny reconstruction method based on inner distance distributions of k-mer pairs in biological sequences

R Tang, Z Yu, J Li - Molecular Phylogenetics and Evolution, 2023 - Elsevier
Alignment-based methods have faced disadvantages in sequence comparison and
phylogeny reconstruction due to their high computational complexity. Alignment-free …

Please Mind the Gap: Indel-Aware Parsimony for Fast and Accurate Ancestral Sequence Reconstruction and Multiple Sequence Alignment including Long Indels

C Iglhaut, J Pečerska, M Gil… - Molecular Biology and …, 2024 - academic.oup.com
Despite having important biological implications, insertion and deletion (indel) events are
often disregarded or mishandled during phylogenetic inference. In multiple sequence …

Deep learning for predicting 16S rRNA gene copy number

J Miao, T Chen, M Misir, Y Lin - Scientific Reports, 2024 - nature.com
Culture-independent 16S rRNA gene metabarcoding is a commonly used method for
microbiome profiling. To achieve more quantitative cell fraction estimates, it is important to …

An exploration of whole-genome comparative genomic strategies for polyploid crop genomes

GL Reynolds - 2022 - scholarworks.montana.edu
Genome comparison for large and complex polyploid crop genomes is a highly complex
venture, yet it is critical. Given a rising demand for food coupled with yield-impacting …