Patterning of the cell cortex by Rho GTPases
Abstract The Rho GTPases—RHOA, RAC1 and CDC42—are small GTP binding proteins
that regulate basic biological processes such as cell locomotion, cell division and …
that regulate basic biological processes such as cell locomotion, cell division and …
DOCK8 deficiency: insights into pathophysiology, clinical features and management
Abstract Dedicator of cytokinesis 8 (DOCK8) deficiency is a combined immunodeficiency
that exemplifies the broad clinical features of primary immunodeficiencies (PIDs), extending …
that exemplifies the broad clinical features of primary immunodeficiencies (PIDs), extending …
DOCK family proteins: key players in immune surveillance mechanisms
K Kunimura, T Uruno, Y Fukui - International immunology, 2020 - academic.oup.com
Dedicator of cytokinesis (DOCK) proteins constitute a family of evolutionarily conserved
guanine nucleotide exchange factors (GEFs) for the Rho family of GTPases. Although DOCK …
guanine nucleotide exchange factors (GEFs) for the Rho family of GTPases. Although DOCK …
[HTML][HTML] Conditional peripheral membrane proteins: facing up to limited specificity
K Moravcevic, CL Oxley, MA Lemmon - Structure, 2012 - cell.com
Regulated relocalization of signaling and trafficking proteins is crucial for the control of many
cellular processes and is driven by a series of domains that respond to alterations at …
cellular processes and is driven by a series of domains that respond to alterations at …
Cellular and molecular interactions of phosphoinositides and peripheral proteins
RV Stahelin, JL Scott, CT Frick - Chemistry and physics of lipids, 2014 - Elsevier
Anionic lipids act as signals for the recruitment of proteins containing cationic clusters to
biological membranes. A family of anionic lipids known as the phosphoinositides (PIPs) are …
biological membranes. A family of anionic lipids known as the phosphoinositides (PIPs) are …
Structure of the DOCK2− ELMO1 complex provides insights into regulation of the auto-inhibited state
DOCK (dedicator of cytokinesis) proteins are multidomain guanine nucleotide exchange
factors (GEFs) for RHO GTPases that regulate intracellular actin dynamics. DOCK proteins …
factors (GEFs) for RHO GTPases that regulate intracellular actin dynamics. DOCK proteins …
Identification of novel families and classification of the C2 domain superfamily elucidate the origin and evolution of membrane targeting activities in eukaryotes
Eukaryotes contain an elaborate membrane system, which bounds the cell itself, nuclei,
organelles and transient intracellular structures, such as vesicles. The emergence of this …
organelles and transient intracellular structures, such as vesicles. The emergence of this …
Activation of Rac1 by Src-dependent phosphorylation of Dock180Y1811 mediates PDGFRα-stimulated glioma tumorigenesis in mice and humans
Two hallmarks of glioblastoma multiforme, the most common malignant brain cancer in
humans, are aggressive growth and the ability of single glioma cells to disperse throughout …
humans, are aggressive growth and the ability of single glioma cells to disperse throughout …
CpG island methylation profiling in human salivary gland adenoid cystic carcinoma
A Bell, D Bell, RS Weber, AK El‐Naggar - Cancer, 2011 - Wiley Online Library
BACKGROUND: DNA methylation is a fundamental epigenetic event associated with
physiologic and pathologic conditions, including cancer. Hypermethylation of CpG islands at …
physiologic and pathologic conditions, including cancer. Hypermethylation of CpG islands at …