Membrane permeabilizing peptides (MPPs) are as ubiquitous as the lipid bilayer
membranes they act upon. Produced by all forms of life, most membrane permeabilizing …

In the last 20 years, an increasing number of studies have been reported on membrane
active peptides. These peptides exert their biological activity by interacting with the cell …

Computational 'microscopy'refers to the use of computational resources to simulate the
dynamics of a molecular system. Tuned to cell membranes, this computational …

Biophysical and structural investigations are presented with a focus on the membrane lipid
interactions of cationic linear antibiotic peptides such as magainin, PGLa, LL37, and melittin …

Even 30 years after the discovery of magainins, biophysical and structural investigations on
how these peptides interact with membranes can still bear surprises and add new …

Abstract PGLa and magainin 2 (MAG2) are amphiphilic α-helical membranolytic peptides
from frog skin with known synergistic antimicrobial activity. By systematically mutating …

Many antimicrobial peptides (AMPs) selectively target and form pores in microbial
membranes. However, the mechanisms of membrane targeting, pore formation and function …

We review the use of molecular dynamics (MD) simulation as a drug design tool in the
context of the role that the lipid membrane can play in drug action, ie, the interaction …

Biophysical and structural studies of peptide–lipid interactions, peptide topology and
dynamics have changed our view on how antimicrobial peptides insert and interact with …

Membrane-active antimicrobial peptides (AMPs) are challenging to study experimentally, but
relatively easy to investigate using molecular dynamics (MD) computer simulations. For this …