Colorectal cancer (CRC) remains a leading cause of cancer-related deaths in the United
States. Although immunotherapy has dramatically changed the landscape of treatment for …

Background The pan-immune-inflammation value (PIV) has been reported as a novel
prognostic biomarker in multiple malignancies. The aim of this study is to investigate the …

Esophageal cancer (EC) is a common malignant gastrointestinal (GI) cancer in adults.
Although surgical technology combined with neoadjuvant chemoradiotherapy has advanced …

Objective To explore the efficacy and safety of single-agent programmed cell death protein-1
(PD-1) inhibitor in the neoadjuvant treatment of patients with mismatch repair-deficient …

Patients with the heritable cancer disease, Lynch syndrome, carry germline variants in the
MLH1, MSH2, MSH6 and PMS2 genes, encoding the central components of the DNA …

Microsatellite instability (MSI) became the spotlight after the US FDA's approval of MSI as an
indication of immunotherapy for cancer patients. Immunohistochemical detection of loss of …

Due to the heterogeneity of colon cancer, surgery, chemotherapy, and radiation are
ineffective in all cases. The genomic profile and biomarkers associated with the process are …

Simple Summary The DNA damage response pathway plays a critical role in maintaining
genomic integrity. Therefore, inhibition of activation of cell-cycle checkpoints involved in this …

Objective The aim of this study was the evaluation radiomics analysis efficacy performed
using computed tomography (CT) and magnetic resonance imaging in the prediction of …

TIM4 has previously been associated with antitumor immunity, yet the pattern of expression
and the function of this receptor across human cancer tissues remain poorly explored. Here …