Androgens and the androgen receptor (AR) play important roles in male fertility, although
the detailed mechanisms, particularly how androgen/AR influences spermatogenesis in …

Spermatogenesis is a remarkably complex but precise process yielding highly differentiated
haploid germ cells from diploid stem cells. Although many factors have been implicated in …

Androgen-binding protein (ABP) is a testicular glycoprotein (French and Ritzén, 1973;
Danzo et al, 1974; Danzo and Black, 1990) that binds androgens with high affinity …

Spermatogenesis occurs within the seminiferous tubules of the testis, in close association
with the somatic cells of the seminiferous epithelium, the Sertoli cells. At the completion of …

The critical influence of follicle stimulating hormone (FSH) on male fertility relates both to its
impact on Sertoli cell proliferation in perinatal life and to its influence on the synthesis of …

Testosterone is one essential endocrine factor for gametogenesis in male mammals. The
other hormone associated with spermatogenesis is follicle-stimulating hormone (FSH). A …

Although many genes are expressed selectively in Sertoli cells, regulatory sequences
sufficient to drive Sertoli cell-specific expression in the postnatal and adult testis in vivo have …

In mammals, the contribution of the Y chromosome is paramount for male sexual
determination; however, the presence of a single functional X chromosome is also of …

Although the role of homeodomain transcription factors during embryogenesis is well
known, their developmental function in postnatal animals is only beginning to be …

Androgens are the main hormones responsible for the induction of the male phenotype. This
process involves a complex combination of reversible and irreversible effects. As for other …