Cell invasion through basement membrane barriers is crucial during many developmental
processes and in immune surveillance. Dysregulation of invasion also drives the pathology …

BACKGROUND In vertebrates, the central and peripheral nervous system (CNS and PNS,
respectively) are segregated at the cellular level. The CNS encompasses the brain and …

Invasive cells use transient, energy-consuming protrusions to breach basement membrane
(BM) barriers. Using the ATP sensor PercevalHR during anchor cell (AC) invasion in …

The damage or degeneration of spiral ganglion neurons (SGNs) can impair the auditory
signals transduction from hair cells to the central auditory system, and cause significant …

Microglia are the resident macrophages of the CNS that serve critical roles in brain
construction. Although human brains contain microglia by 4 weeks gestation, an …

The overproduction of cells and subsequent production of debris is a universal principle of
neurodevelopment. Here, we show an additional feature of the developing nervous system …

The nervous system requires metabolites and oxygen supplied by the neurovascular
network, but this necessitates close apposition of neurons and endothelial cells. We find …

Glial cells are essential for functionality of the nervous system. Growing evidence
underscores the importance of astrocytes; however, analogous astroglia in peripheral …

Spontaneous Ca2+ transients of neural cells is a hallmark of the developing nervous
system. It is widely accepted that chemical signals, like neurotransmitters, contribute to …

Neural cells are segregated into their distinct central nervous system (CNS) and peripheral
nervous system (PNS) domains. However, at specialized regions of the nervous system …